University of Groningen
Antidepressant treatment during pregnancy: For better or worse?
Houwing, Danielle
DOI:
10.33612/diss.130768368
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Houwing, D. (2020). Antidepressant treatment during pregnancy: For better or worse? Neurodevelopmental outcomes in rat offspring. Rijksuniversiteit Groningen. https://doi.org/10.33612/diss.130768368
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ANTIDEPRESSANT TREATMENT
DURING PREGNANCY:
FOR BETTER OR WORSE?
NEURODEVELOPMENTAL OUTCOMES IN RAT OFFSPRING
DANIELLE J. HOUWING
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Th e printing of this thesis was fi nancially supported by the University of Groningen, the Graduate School of Science and Engineering (GSSE) and Noldus Information Technology.
Research conducted at the university of Tromsø, Norway, was supported by a KNAW ter Meulen travel grant.
Cover design and layout: Elisa Calamita, www.persoonlijkproefschrift .nl. Printing: Ridderprint | www.ridderprint.nl
ISBN (printed version): 978-94-034-2569-6 ISBN (electronic version): 978-94-034-2568-9
Antidepressant treatment during pregnancy:
for better or worse?
Neurodevelopmental outcomes in rat offspring
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op vrijdag 4 september 2020 om 16.15 uur
door
Danielle Josephina Houwing geboren op 10 januari 1990
te Arnhem
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Promotores
Prof. dr. J.D.A. Olivier Prof. dr. M.J.H. Kas
Copromotor
Dr. S.F. de BoerBeoordelingscommissie
Prof. dr. J.R. Homberg Prof. dr. L.J.M.J. Vanderschuren Prof. dr. G. van DijkPromotores
Prof. dr. J.D.A. Olivier Prof. dr. M.J.H. Kas
Copromotor
Dr. S.F. de BoerBeoordelingscommissie
Prof. dr. J.R. Homberg Prof. dr. L.J.M.J. Vanderschuren Prof. dr. G. van DijkTo my family
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CONTENTS
Chapter 1 General introduction 9 Chapter 2 Perinatal fluoxetine exposure disrupts the circadian response to
a phase-shifting challenge in female rats 39 Chapter 3 Perinatal fluoxetine exposure changes social and stress-coping
behavior in adult rats housed in a seminatural environment 67 Chapter 4 Maternal separation induces anhedonia in female heterozygous
serotonin transporter knockout rats 109 Chapter 5 Subjecting dams to early life stress and perinatal fluoxetine
treatment differentially alters social behavior in young and adult rat offspring
125
Chapter 6 Perinatal fluoxetine treatment and dams’ early life stress history have opposite effects on aggressive behavior while having little impact on sexual behavior of male rat offspring
157
Chapter 7 Perinatal fluoxetine treatment and dams’ early life stress history alter affective behavior in rat offspring depending on serotonin transporter genotype and sex
181
Chapter 8 General discussion 205
Appendix I English summary 238
Appendix II Nederlandse samenvatting 248
Appendix III Dankwoord 260
Appendix IV About the author 266 Appendix V List of publications 268
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