CONTENTS
1. Introduction 9
SECTION 1. Physiology
2. Modeling the ventilatory response to carbon dioxide in humans after bilateral 15 and unilateral carotid body resection (CBR)
3. Antioxidants prevent depression of the acute hypoxic ventilatory response 25 by subanesthetic halothane
SECTION 2. Pharmacology
4. Propofol for monitored anesthesia care: Implications on hypoxic control of 37 cardiorespiratory responses
5. Respiratory sites of action of propofol: Absence of depression of peripheral 49 chemoreflex loop by low-dose propofol
6. Response surface modeling of alfentanil-sevoflurane interaction on cardio- 59 respiratory control and bispectral index
7. Response surface modeling of remifentanil-propofol interaction on cardio- 75 respiratory control and bispectral index
8. Respiratory depression by tramadol in the cat: involvement of opioid receptors? 93
SECTION 3. Postoperative Care
9. The Ward 9 Study or Ventilatory responses after major abdominal surgery 105 and intensive care
10. Summary and Conclusions — Samenvatting en Conclusies 119
11. References 131
List of Abbreviations and Symbols 141
Curriculum Vitae and List of Publications 143
