Cover Page
The handle
http://hdl.handle.net/1887/80759
holds various files of this Leiden University
dissertation.
Author: Grand Moursel, L.
Title: Molecular pathology of hereditary cerebral hemorrhage with amyloidosis-Dutch
type
Molecular pathology of hereditary cerebral
hemorrhage with amyloidosis-Dutch type
Molecular pathology of hereditary cerebral
hemorrhage with amyloidosis-Dutch type
Proefschrift
Ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus Prof. mr. C.J.J.M. Stolker, volgens besluit
van het College voor Promoties te verdedigen op Donderdag 21 November 2019 klokke 10.00 uur.
door
Laure Grand Moursel
geboren te Angoulême, Frankrijk in 1979 © 2019, Laure Grand Moursel
ISBN: 978-94-93184-08-4
Layout and printing: Guus Gijben, proefschrift-aio.nl
Copyrights of published material in chapters 2 to 6 lies with the publisher of the journal listed at the beginning of each chapter.
Table of contents
Chapter 1: General introduction
Chapter 2: Amyloid β in hereditary cerebral hemorrhage with amyloidosis-Dutch type
Chapter 3: TGFβ pathway deregulation and abnormal phospho-SMAD2/3 staining in hereditary cerebral hemorrhage with amyloidosis-Dutch type
Chapter 4: Cerebral amyloid angiopathy with vascular iron accumulation and calcification: a high-resolution MRI-histopathology study
Chapter 5: Osteopontin and phospho-SMAD2/3 are associated with calcification of vessels in D-CAA, an hereditary cerebral amyloid angiopathy
Chapter 6: Brain Transcriptomic Analysis of Hereditary Cerebral Hemorrhage With Amyloidosis-Dutch Type
Chapter 7: General discussion Appendices Summary Nederlandse samenvatting List of publications List of abbreviations Curriculum vitae Acknowledgements Promotor
Prof. dr. M.A. van Buchem Co-promotores
Dr. L. van der Weerd Dr. W.M.C. van Roon-Mom Leden promotiecommissie: Prof. dr. P. ten Dijke
Prof. dr. Ir. S.M. van der Maarel Prof. dr. M.J.H. Wermer
Dr. M.M.M. Wilhelmus (VUmc, Amsterdam) Prof. dr. H.E. de Vries (VUmc, Amsterdam)
7 27 49 75 91 111 135 153 153 157 161 165 169 171 The work presented in this thesis was supported by grants from the Bontius
stichting (Leiden), the Dutch CAA foundation (Rotterdam) and by the Netherlands Organization for Scientific Research (NWO, The Hague), under research program VIDI, project ‘’Amyloid and vessels’’, number 864.13.014.
