Cover Page
The handle http://hdl.handle.net/1887/137306 holds various files of this Leiden University
dissertation.
Author: Sow, H.S.
Cover Page
The handle http://hdl.handle.net/1887/137306 holds various files of this Leiden University
dissertation.
Author: Sow, H.S.
Stellingen behorende bij het proefschrift
“In vivo mechanisms of antibody-based cancer immunotherapy” 1. Engagement to FcγR does not hamper the therapeutic efficacy of
anti-PD-L1 mAb in mice (this thesis)
2. Anti-PD-L1 blockade combined with TGF-β inhibition increases influx of CD8+ T cells in the tumor microenvironment for
effective tumor control (this thesis)
3. TLR ligands and IL-2 improve the therapeutic efficacy of anti-TRP-1 antibody therapy of melanoma in mice by enhancing cooperative innate and adaptive immune responses (this thesis) 4. High numbers of pre-existing tumor-infiltrating lymphocytes
(TILs) are associated with stronger response to anti-neu mAb therapy (this thesis)
5. Characterization of antibody-FcγR interactions for individual therapies is key to guide the selection of the IgG isotypes that mediates the desired effector function (Furness et al.,2014 Trends in Immunology, 35: p290-298)
6. For the improvement of therapies based on TGF-β inhibition, it is important to gain a mechanistic understanding of TGF-β inhibition in the tumor immune microenvironment and how this affects the generation of adequate antitumor immune responses (Zhao et al., 2018 Cancer Immunol Res; 6, 1459-1471)
7. Identification of the relevant effector cells required for antibody therapy is essential for the development of rational combination therapies (Furness et al.,2014 Trends in Immunology, 35: p290-298)
8. The utility of BALB/c-NeuT mammary mouse model in the in
vivo analysis of FcγR function is hampered by the lack of FcγR
9. A better understanding of murine tumor models is required to enable appropriate model selection which permits adequate extrapolation of the preclinical results to the patient (Mosely et al., 2017 Cancer Immunol Res; 5, p29-41)
10. All scientific data should be published, positive and negative, so long as it advances the state of knowledge (Enago 2018). Negative results are also crucial and have underestimated impact on the progress of our scientific understanding
11. One of the crucial PhD candidates’ tasks is to prevent professors or supervisors from freeing precious empty slots in their agendas 12. Empty your mind, be shapeless, formless - like water. Put water
