Leukocytes at the maternal-fetal interface in human pregnancy
Sindram-Trujillo, A.P.Citation
Sindram-Trujillo, A. P. (2006, January 24). Leukocytes at the maternal-fetal interface in human pregnancy. Retrieved from https://hdl.handle.net/1887/4270
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in theInstitutional Repository of the University of Leiden Downloaded from: https://hdl.handle.net/1887/4270
S
TELLINGEN1. In uncomplicated term pregnancy, there are significantly higher percentages of CD56brightCD16- NK cells, CD3+TCRγδ+ cells and CD3+ T cells expressing markers CD25, HLA-DR, CD45RO, or CD69 in the decidua parietalis in comparison to the decidua basalis. (this thesis)
2. Labor is associated with a differential distribution and proportion of decidual leukocyte subpopulations, including a higher percentage of macrophages and CD56dimCD16+ NK cells and a lower percentage of certain CD3+ T cell subsets. (this thesis)
3. Leukocytes in term decidua basalis and parietalis are capable of initiating and stimulating a classical alloimmune response against fetal and allogeneic cells. (this thesis)
4. Aberrant immunoregulation may play a role in intrauterine growth restriction with and without preeclampsia, as suggested by differences in decidual leukocytes when compared with normal pregnancy. (this thesis) 5. The immunological problem of pregnancy may be formulated thus: how does
the pregnant mother contrive to nourish within itself, for many weeks or months, a foetus that is an antigenically foreign body? (Sir Peter Medawar, the founding father of the modern field of Reproductive Immunology)
6. Acceptance of a pregnancy should lead to a modulation of the societal career response preventing rejection by the latter.
7. Understanding the mechanisms involved in ischemia reperfusion injury provides insight not only into the field of transplantation, but also immunology and obstetrics.
8. While decidual leukocytes play an essential role at the maternal-fetal interface in utero, patience and love establish maternal tolerance in the post-partum period.
9. It’s the “unknown” in life that makes it all so terrifyingly intimidating and intensely thrilling!
A
CKNOWLEDGEMENTSI would like to sincerely thank my supervisors, Frans Claas and Dave Roelen from the Department of Immunohematology and Blood Transfusion, and Humphrey Kanhai and Sicco Scherjon from the Department of Obstetrics. Thank you for your expansive fund of knowledge, your patience, your humor and especially, your support! Your camaraderie made the collaboration a scientific delight!
To the great researchers, analysts and staff of the IHB, thank you so much for enjoying countless cups of tea and coffee. From you, I learned the most about Dutch culture. Because of you, I never had to complete the inburgeringcursus. Thank you for enduring my strange accent and English/Dutch language mengsel. You are a wonderful group of people with such a wide variety of personalities and interests, from saxophone, gardening, cooking, and volleyball to travelling, sailing and salsa dancing. It was a pleasure and a privilege to work with you and learn from you.
To the biebers, both new and old, and to the biebers-by-association, Paula, Els, Ellen, Minke, Corine, Danielle, Jolien, Marlies, Martin, Susan, Liesbeth, Marloes, Sebastiaan, Karin, Yvonne, Berit en Berna, it was always such a pleasure to come over to your room, ask questions, find "drop" en "koekjes" and always find answers. I never imagined so many people could fit and "work" in one room! Many thanks to Paula, who so patiently worked with me those first few months on the FACS; to Jolien, who so diligently worked with me the last months to finish up all of our projects and continued to kindly help me with every aspect of this thesis while I was so many miles away, and to Ingrid and Vera, who generously organized the financial support of this thesis and managed the communication with the University. Many thanks as well to the people from the "oude koffiekamer," our quiet room with a “window,” our own United Nations, with an American, Swede, Korean, Greek, Dutch and Irish all in one room. To the Verloskunde lab, Albert, Godelieve, Karin, Elles, Tamara, Barbara and Margriet, it was always a pleasure to work on the other side of the “brug.”
Nederlandse samenleving. Ten things I recommend all Americans should do if living and working in Holland are as follows: Eet drop, fiets in Amsterdam, weet wanneer er koffiepauze is, maak boerenkool, leer wat “football” betekent in de rest van de wereld, schaaf kaas, weet dat een boterham bestaat uit maar één sneedje brood, leer hoe je “gezellig” en “Scheveningen” uitspreekt, drink melk of bier als je dorst hebt, ga naar buiten als de zon schijnt!
Much gratitude to my dearest friends, VA and Jennifer, for always making me laugh and keeping in touch so many time zones and working lives apart; to the many great teachers, Bob Storms, Tom Dowd, Pat Dodson, Gordon Bingham, Carol Rubinstein, Pat Kane, Justine Linville, Doug Pierce, Peter Funk, Van Brown, and the countless others at FCDS, UNC School of Medicine and Duke University; and to all those who continue to help me learn Dutch: David, my colleagues, the Sindram and Fleminger families, Trudy - my own personal lerares nederlands, Doe Maar, Metro, Story en de Nederlandstalige ondertiteling.
