Shedding light on anti-estrogen resistance and antigen presentation through biophysical techniques

A Training series consisting of patients treated with tamoxifen for metastatic disease, B Validation series consisting of premenopausal patients who have participated in

In breast cancer, the exact role of ERβ is still under dis- cussion, but high expression levels are correlated with good prognosis, thought to function by inhibiting ERα

CLIP is then exchanged for one of these fragments with help of the chaperone HLA-DM, and the peptide-loaded MHC class II molecules are transported to the plasma

and DO/CFP showed FRET with normal efficiency, no FRET was detected between DR/CFP and DM/YFP at the limiting membrane of these swollen structures, analogous to the

Rab7, thus, recruits two proteins with diverse functions in the con- trol of dynein motor–driven transport: RILP for motor binding and ORP1L for transport to the

(E) NPC1, cholesterol and late endosomal clustering. MelJuSo cells were transfected with control or NPC1 siRNA and subsequently mRFP-∆ORD. Subsequently, cells were fi

port of MHC class II molecules, Ii directs both their loading with antigenic peptides and their delivery to T cells. The novelty of our present work lies in three aspects:

Do vesicles destined to fuse with lysosomes expose high cholesterol levels on their cytosolic leaflet, and after antigen loading and CD70 acquisition decrease