Citation
Meer, R. W. van der. (2008, November 20). Myocardial Steatosis and Left Ventricular Function in Type 2 Diabetes Mellitus : Assessed with Magnetic Resonance Imaging and Spectroscopy. Retrieved from https://hdl.handle.net/1887/13290
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Myocardial Steatosis and Left Ventricular Function in Type 2 Diabetes Mellitus
Assessed with Magnetic Resonance Imaging and Spectroscopy
Myocardial Steatosis and Left Ventricular Function in Type 2 Diabetes Mellitus
Assessed with Magnetic Resonance Imaging and Spectroscopy
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op
donderdag 20 november 2008 klokke 16.15 uur
door
Rutger Wouter van der Meer geboren te Zwartewaal
in 1978
Overige leden: Prof. dr. P.R. Luijten
Universitair Medisch Centrum Utrecht Prof. dr. K. Nicolay
Technische Universiteit Eindhoven
The research described in this thesis was carried out at the departments of Radiology (head: Prof. dr. J.L. Bloem) and Endocrinology (head: Prof. dr. J.A. Romijn) of the Leiden University Medical Center.
Publication of this thesis was financially supported by Foundation Imago te Oegstgeest and by the J.E. Jurriaanse Stichting.
Additional financial support from the Netherlands Heart Foundation and the Netherlands Diabetes Foundation is gratefully acknowledged.
Contents
Chapter 1 General introduction and outline 9
Part I:
Technical evaluation
Chapter 2 Cardiovascular molecular magnetic resonance imaging Eur J Nucl Med Mol Imaging 2007:34:S99-S104
17
Chapter 3 Metabolic imaging of myocardial triglyceride content:
reproducibility of 1H-magnetic resonance spectroscopy with respiratory navigator gating in volunteers
Radiology 2007:245(1):251-257
29
Part II:
Effects of myocardial triglyceride accumulation in the healthy population
Chapter 4 Short-term caloric restriction induces accumulation of myocardial triglycerides and decreases left ventricular diastolic function in healthy subjects
Diabetes 2007:56(12):2849-2853
45
Chapter 5 Progressive caloric restriction induces dose-dependent changes in myocardial triglyceride content and diastolic function in healthy men
J Clin Endocrinol Metab 2008:93(2):497-503
59
Chapter 6 Effects of short-term high-fat, high-energy diet on hepatic and myocardial triglyceride content in healthy men
J Clin Endocrinol Metab 2008:93(7):2702-2708
73
Chapter 7 The ageing male heart: myocardial triglyceride content as independent predictor of diastolic function
Eur Heart J 2008:29(12):1516-1522
89
6
aortic distensibility, and cardiac function in uncomplicated type 2 diabetes mellitus
J Cardiovasc Magn Reson 2007:9(4):645-651
Chapter 10 Myocardial steatosis is an independent predictor of diastolic dysfunction in type 2 diabetes mellitus
J Am Coll Cardiol in press 2008
137
Chapter 11 Pioglitazone improves cardiac function and alters myocardial substrate metabolism without affecting cardiac triglyceride accumulation and high-energy phosphate metabolism in patients with well-controlled type 2 diabetes mellitus Submitted
153
Chapter 12 Summary and conclusions 175
Samenvatting en conclusies 181
List of publications 185
Acknowledgements 191
Curriculum vitae 193
