The handle http://hdl.handle.net/1887/29815 holds various files of this Leiden University dissertation
Author: Heuvel, Joost van den
Title: The evolution and plasticity of life histories upon variation in nutrition : an ageing focused integrative approach
Issue Date: 2014-11-25
The evolution and plasticity of life histories upon variation in nutrition
an ageing focused integrative approach
by Joost van de Heuvel
An electronic version of this thesis can be downloaded from:
openacces.leidenuniv.nl
Cover-design by Andreas Plischke
Thesis lay-out by Rene Glas (www.reneglas.com).
Printed by Wörhmann Print Service, Zutphen ISBN: 978-94-6203-680-2
© 2014, ALL RIGHTS RESERVED
The research in this thesis was supported by the Network of Exellence LifeSpan (FP6036894) and the European Union’s Seventh Framework Programme (FP7/2007-2011) under grant agreement number 259679.
The evolution and plasticity of life histories upon variation in nutrition
an ageing focused integrative approach
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College van Promoties te verdedigen op dinsdag 25 november 2014
klokke 15.00 uur
door
Joost van den Heuvel
geboren te Rotterdam in 1984
Promotoren • Prof. dr. Paul M. Brakefield
Universiteit Leiden, Cambridge University (UK)
• Prof. dr. Bas J. Zwaan
Universiteit Leiden, Wageningen Universiteit
Overige leden • Prof. Dr. Thomas B.L. Kirkwood
Newcastle University (UK)
• Dr. Daryl P. Shanley
Newcastle University (UK)
• Prof. Dr. Thomas Flatt
University of Lausanne (CH)
• Dr. Tom de Jong
Universiteit Leiden
• Dr. Marjo Saastamoinen
University of Helsinki (Fi)
C o n t e n t s
Chapter 1 • Introduction 7
Chapter 2 • The predictive adaptive response: Modeling the life history evolution of the butterfly, Bicyclus anynana, in seasonal environments
33
Chapter 3 • A theoretical model of dietary restriction responses in temporally and spatially varying environments
67
Chapter 4 • The plastic fly: the effect of sustained fluctuations in adult food supply on life history traits
95
Chapter 5 • Linking life history trait and transcriptome variation using cyclical nutritional environments in Drosophila melanogaster
121
Chapter 6 • Modeling the relationship between age specific fecundity and lifespan in a cohort of fruit flies
149
Chapter 7 • Linking the life history phenotype to genetic variation using a candidate gene approach in the least killifish Heterandria formosa
169
Chapter 8 • Discussion 215
Nederlandse samenvatting 227
Acknowledgements 235
Curriculum Vitae 239
Publications 241
Authors list 243
The End 245
