University of Groningen
Osteoprotegerin in Fibrotic Disorders Adhyatmika, A.
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Publication date: 2018
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Adhyatmika, A. (2018). Osteoprotegerin in Fibrotic Disorders. University of Groningen.
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Adhyatmika iii STELLINGEN
behorende bij het proefschrift
1. A new trivial name for tumor necrosis factor receptor superfamily 11B, alias osteoprotegerin, may be necessary to emphasize its broader role in tissue repair in addition to protecting bone.
2. Osteoprotegerin plays a significant role in organ fibrosis, especially in the liver (this thesis).
3. Osteoprotegerin expression by organs marks the early phase of fibrosis development that may be exploited as a biomarker (this thesis).
4. Transforming growth factor β is a spider in the web of fibrosis regulation, connecting both interleukin 13 and osteoprotegerin with fibrogenesis (this thesis).
5. There is feed-forward loop between transforming growth factor β and osteoprotegerin, especially in fibroblasts (this thesis).
6. MicroRNA 145-5p is a brake in the feed-forward loop between transforming growth factor β and osteoprotegerin in myofibroblasts (this thesis).
7. The dogma that M2 macrophages are profibrotic is not correct (this thesis). 8. Osteoprotegerin, fibroblasts, and macrophages teach us to avoid blind
stereotyping and to see things in context.
9. A PhD is a marker of academic scholarship, just like OPG as a marker of fibrosis, and both should be used as more than markers.
10. The further the distance, the broader the view; it has taken me 11,611 kms to experience this.
