• No results found

University of Groningen Transplantation of high risk donor livers de Vries, Yvonne

N/A
N/A
Protected

Academic year: 2021

Share "University of Groningen Transplantation of high risk donor livers de Vries, Yvonne"

Copied!
2
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Hele tekst

(1)

University of Groningen

Transplantation of high risk donor livers

de Vries, Yvonne

DOI:

10.33612/diss.133940024

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from

it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date:

2020

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

de Vries, Y. (2020). Transplantation of high risk donor livers: Machine perfusion studies to improve and

predict post transplant hepatobiliary function. University of Groningen.

https://doi.org/10.33612/diss.133940024

Copyright

Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).

Take-down policy

If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.

Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

(2)

Stellingen behorende bij het proefschrift

Transplantation of High Risk Donor Livers

Machine Perfusion Studies To Improve and Predict Post Transplant

Hepatobiliary Function

Yvonne de Vries

1. Galwegcomplicaties na transplantatie dienen te worden beschouwd als het gevolg van een spectrum van verschillende soorten galwegschade.

2. Het beoordelen van biomarkers voor cholangiocytenfunctie- en vitaliteit tijdens normotherme machine perfusie (NMP) is minstens zo belangrijk als het beoordelen van biomarkers voor

hepatocytenfunctie- en vitaliteit.

3. Duale hypotherme geoxygeneerde machine perfusie (DHOPE) en NMP van de lever zijn complementair.

4. Klinische machine perfusie met een op HBOC-201 gebaseerde perfusievloeistof biedt meerdere voordelen ten opzichte van een op humane rode bloed cellen gebaseerde perfusievloeistof .

5. Eind-ischemische DHOPE gevolgd door geleidelijk opwarmen tot NMP is een effectieve en veilige methode om hoog-risico donor levers te resusciteren en te selecteren voor transplantatie. 6. Hypotherme geoxygeneerde machine perfusie via zowel de v. porta

als de a. hepatica verdient de voorkeur boven hypotherme geoxygeneerde machine perfusie via alleen de v. porta 7. 24/7 diensten draaien voor de DHOPE–COR–NMP Trial is tevens

goed voor de gezondheid van de eigen lever.

8. Het gevaar van (super)specialismen is dat men niet meer buiten ‘the box’ wil (en kan) denken.

Referenties

GERELATEERDE DOCUMENTEN

End-Ischemic Dual Hypothermic Oxygenated Machine Perfusion with Static Cold Storage in Preventing Non-Anastomotic Biliary Strictures after Transplantation of Liver Grafts

Currently, the survival rate after transplantation of DCD liver grafts is similar to that of transplantation of donation after brain death (DBD) liver grafts.8,10-12

The patient survival rate of pediatric DCD livers in the current study was in line with that of adult DCD liver grafts (78% versus 80-92% at 1 year respectively).2-5,12,24-26

This study aims to assess whether graft quality assessed by ET-DRI in donation after brain death (DBD) donors has influence on outcome and costs of liver transplantation..

Traditionally, the degree of biliary injury that occurs during and after transplantation was considered to be the main determining factor for NAS.22 Warm and cold ischemia,

Experimental studies have suggested that machine preservation may provide better protection of liver grafts against ischemia–reperfusion injury than the traditional method of

Based on aforementioned studies and some unique properties of HBOC, such as the availability and the ability to be used at low temperatures, a clinical trial

Transplantation of high-risk donor livers after resuscitation and viability assessment using a combined protocol of oxygenated hypothermic, rewarming and