University of Groningen
Pharmacoeconomics of prophylactic, empirical, and diagnostic-based antibiotic treatments
Purba, Abdul
DOI:
10.33612/diss.128518764
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Purba, A. (2020). Pharmacoeconomics of prophylactic, empirical, and diagnostic-based antibiotic
treatments: Focus on surgical site infection and hospitalized community-acquired pneumonia. University of Groningen. https://doi.org/10.33612/diss.128518764
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Pharmacoeconomics of prophylactic,
empirical, and diagnostic-based
antibiotic treatments
Focus on surgical site infection and
hospitalized community-acquired pneumonia
Pharmacoeconomics of prophylactic, empirical, and diagnostic-based antibiotic treatments
Focus on surgical site infection and hospitalized community-acquired pneumonia
Author: Abdul Khairul Rizki Purba
Cover: Abdul Khairul Rizki Purba (concept) and zannoism.com (design) Lay-out: Douwe Oppewal
Printing: Ipskamp Printing, Enschede ISBN (book): 978-94-034-2805-5
ISBN (electronic version): 978-94-034-2806-2
This thesis was funded by grants from DIKTI BPPLN scholarship (the scholarship from Directorate General of Resources for Science, Technology and Higher Education, Ministry of Research, Technology and Higher Education, Republic of Indonesia), from Universitas Airlangga, and from the University Medical Center Groningen, the Netherlands. Also, the work presented in this thesis was performed at the Department of Health Sciences and the Department of Medical Microbiology of the University Medical Center Groningen. Financial support for printing this thesis was kindly provided by the University of Groningen and the Groningen University for Drug Exploration (GUIDE) of the Graduate School of Medical Sciences (GSMS).
Copyright, 2020, Abdul Khairul Rizki Purba
All rights reserved. No part of this thesis may be reproduced or transmitted in any form or by any means, electronically or mechanically by photocopying, recording, or otherwise, without written permission of the author. The copy right of previously published chapters of this thesis remains with the publisher or journal.
Pharmacoeconomics of
prophylactic, empirical, and
diagnostic-based antibiotic
treatments
Focus on surgical site infection and hospitalized
community-acquired pneumonia
PhD thesis
to obtain the degree of PhD at the
University of Groningen
on the authority of the
Rector Magnificus Prof. C. Wijmenga
and in accordance with
the decision by the College of Deans.
This thesis will be defended in public on
Wednesday 8 July 2020 at 12.45 hours
by
Abdul Khairul Rizki Purba
born on 22 February 1984
in Surabaya, Indonesia
Pharmacoeconomics of prophylactic, empirical, and diagnostic-based antibiotic treatments
Focus on surgical site infection and hospitalized community-acquired pneumonia
Author: Abdul Khairul Rizki Purba
Cover: Abdul Khairul Rizki Purba (concept) and zannoism.com (design) Lay-out: Douwe Oppewal
Printing: Ipskamp Printing, Enschede ISBN (book): 978-94-034-2805-5
ISBN (electronic version): 978-94-034-2806-2
This thesis was funded by grants from DIKTI BPPLN scholarship (the scholarship from Directorate General of Resources for Science, Technology and Higher Education, Ministry of Research, Technology and Higher Education, Republic of Indonesia), from Universitas Airlangga, and from the University Medical Center Groningen, the Netherlands. Also, the work presented in this thesis was performed at the Department of Health Sciences and the Department of Medical Microbiology of the University Medical Center Groningen. Financial support for printing this thesis was kindly provided by the University of Groningen and the Groningen University for Drug Exploration (GUIDE) of the Graduate School of Medical Sciences (GSMS).
Copyright, 2020, Abdul Khairul Rizki Purba
All rights reserved. No part of this thesis may be reproduced or transmitted in any form or by any means, electronically or mechanically by photocopying, recording, or otherwise, without written permission of the author. The copy right of previously published chapters of this thesis remains with the publisher or journal.
Supervisors
Prof. M.J. Postma
Prof. A.W. Friedrich
Co-supervisor
Dr. J.W. Dik
Assessment Committee
Prof. Kuntaman
Prof. B. Wilffert
Prof. J.C. Wilschut
Paranymphs
Erley F. Lizarazo Forero
M. Rifqi Rokhman
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CONTENTS
Part 1. Introduction 11
Chapter 1 General introduction 13
Chapter 2 The burden and costs of sepsis and reimbursement of its treatment in
a developing country: An observational study on focal infections in Indonesia 21
Part 2. Prophylactic antibiotics for surgical site infection prevention 43
Chapter 3 Prevention of surgical site infections: A systematic review of cost analyses
in the use of prophylactic antibiotics 45
Chapter 4 The impacts of deep surgical site infections on readmissions, length of stay,
and costs: A matched case-control cohort study in an academic hospital
in the Netherlands 81
Part 3. Empirical antibiotics for hospitalized
community-acquired pneumonia 97
Chapter 5 Multidrug-resistant infections among hospitalized adults with
community-acquired pneumonia in an Indonesian tertiary referral hospital 99
Chapter 6 Cost-effectiveness of culture-based versus empirical antibiotic treatment
for hospitalized adults with community-acquired pneumonia in Indonesia:
A real-world patient-database study 119
Part 4. Discussion 143
Chapter 7 General discussion and future perspectives 145
Chapter 8 Appendix: Laboratory findings as predictors of sepsis mortality
among adult patients in a general hospital in Indonesia 155
Addendum 163 Summary 164 Samenvatting 168 Ringkasan 172 Acknowledgments 176 Curriculum vitae 185 List of publications 189 Biography 190
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