University of Groningen
Biomarkers in the differential diagnosis of dementia Reesink, Fransje Elisabeth
DOI:
10.33612/diss.96360985
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Publication date: 2019
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Reesink, F. E. (2019). Biomarkers in the differential diagnosis of dementia: cerebrospinal fluid compounds-and nuclear molecular imaging tracers. Rijksuniversiteit Groningen. https://doi.org/10.33612/diss.96360985
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Biomarkers in the differential
diagnosis of dementia
Cerebrospinal fluid compounds- and nuclear
molecular imaging tracers
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 18 september 2019 om 11.00 uur
door
Fransje Elisabeth Reesink
geboren op 2 mei 1975 te Amsterdam
Promotores
Prof. dr. P.P. De Deyn Prof. dr. R.A.J.O. Dierckx
Copromotores
Dr. A.T.M. Willemsen Dr. B.M. de JongBeoordelingscommissie
Prof. dr. P. Cras Prof. dr. J. Booij Prof. dr. H.P.H. Kremer2
Contents:
1. Introduction 3
Part 1: Cerebrospinal fluid (CSF) biomarkers in dementia 12
2. Perspectives of CSF biomarkers in dementia: the past and present 3. CSF markers for differential dementia diagnosis in a large memory 20 clinic cohort ( Neurology, 2012)
4. CSF α-Synuclein biomarkers: not diagnostic but related to cognitive 35 decline in Dementia with Lewy Bodies ( J. AD, 2010)
Part 2: Molecular Imaging biomarkers in dementia 49
5. Nuclear imaging in Frontotemporal dementia
(PET and SPECT in Neurology, Springer-Verlag Berlin Heidelberg 2014)
6. The cerebral metabolic topography of Dementia with Lewy Bodies 70 7. Crossed Cerebellar Diaschisis in Alzheimer’s Disease 87
(Current Alzheimer Research 2018)
8. Relative cerebral flow from dynamic PIB scans as an alternative for 107 FDG scans in Alzheimer’s disease PET studies (PLoS One, 2019)
9. Diagnostic classification following a blinded assessment of combined PIB- 143 and FDG-PET in distinct profiles of Dementia; Preliminary results of the
‘Dual PET’ study
10. General discussion 159
Nederlandse samenvatting (summary in Dutch) Dankwoord
List of publications Curriculum vitae
