Identification of therapeutic targets in coronary artery disease: from patient to mice and back Kraaijeveld, A.O.

Since the direct effect of aging on atherosclerotic lesion initiation and progression is dif- ficult to address in humans, an animal model is imperative. However, most

The temporal Qk gene expression analysis strengthens this hypothesis, while Qk expression was significantly raised seven days following femoral cuff placement in wild

To map the effects of MEF2 activity observed on endothelial cells in vivo, we performed in vitro Matrigel and proliferation assays after infection of cells with Ad-caMEF2,

Furthermore, we studied chemokine receptor expression in circulating peripheral blood mononuclear cells (PBMCs) and specifically focussed on the receptors for CCL5 (CCR1, CCR3,

Vervolgens zijn de chemokines CCL18 (PARC) en CCL3 (MIP-1α), welke beiden in verhoogde mate worden aange- troffen ten tijde van een ACS, onderwerp van nadere studie naar hun

Vanaf januari 2005 werd begonnen met het in dit proefschrift beschreven onderzoek als AGIKO Cardiologie (opleider prof. van der Wall), verbonden aan het Leiden Amsterdam Center

Ondanks het feit dat het CCL18 gen alleen voorkomt in primaten, kunnen experimentele studies naar de effecten van CCL18 in muizen toch veel inzicht verschaffen in de

Peripheral blood cells were stained with HLA-A2.1 tetramers containing the tyrosinase368–376 peptide followed by staining with a panel of lineage antibodies, as described in