Naloxone : actions of an antagonist Dorp, E.L.A. van

Naloxone : actions of an antagonist

Dorp, E.L.A. van

Citation

Dorp, E. L. A. van. (2009, June 24). Naloxone : actions of an antagonist. Retrieved from https://hdl.handle.net/1887/13865

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/13865

Note: To cite this publication please use the final published version (if applicable).

Naloxone:

actions of an antagonist

proefschrift

ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. P.F. van der Heijden,

volgens besluit van het College voor Promoties te verdedigen op woensdag 24 juni 2009

klokke 16.15 uur

door

Eveline Louise Arianna van Dorp geboren te Leiden

in 1982

Promotiecommissie

Promotor: Prof. dr. A. Dahan Co-promotor: dr. E.Y. Sarton

Overige leden: Prof. B. Kest, PhD (College of Staten Island, NY, USA) Prof. dr. M. Marcus (Universiteit Maastricht)

Prof. dr. J.W. van Kleef Prof. dr. L.P.H.J. Aarts dr. L.J.S.M. Teppema

It’s too late to change events It’s time to face the consequence For delivering the proof

In the policy of truth

Depeche Mode – Policy of Truth

To all of those who don’t fit in

The investigations in this thesis were performed in the Anesthesia and Pain Research Unit under the supervision of Prof. Dr. A. Dahan, except for those in Chapter 2, which were performed in the Animal Research Laboratory of the Department of Anesthesi- ology under the supervision of Dr. L.J.S.M. Teppema. Chapter 5 was a collaboration between the Anesthesia and Pain Research unit (human experiments) and the labora- tory of Dr. Benjamin Kest of Staten Island University, NY, USA (animal experiments).

Copyright: c 2009, Eveline L.A. van Dorp, Leiden, The Netherlands Cover design by Gijs Alewijn

Printed by Drukkerij Labor Vincit, Leiden ISBN:978-90-74384-07-0

Typeset in L^ATEX 2ε

Contents

I Introduction 1

1 Introduction 3

II Respiration 9

2 Antagonism of opioid induced respiratory depression in cats 11 3 Naloxone reversal of buprenorphine-induced respiratory depression 29 4 PK/PD analysis of naloxone use in respiratory depression 43

III Analgesia and hyperalgesia 59

5 Naloxone and M6G induced hyperalgesia 61

IV Drug addiction 77

6 Naloxone treatment in opioid addiction 79

V Conclusions 95

7 Summary and conclusions 97

8 Samenvatting en conclusies 103

Curriculum Vitae 109

List of Publications 110

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