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The handle http://hdl.handle.net/1887/70209 holds various files of this Leiden University dissertation.

Author: Aart, L.T. van der

Title: Another Brick in the Wall: the role of the actinobacterial cell wall in antibiotic

resistance, phylogeny and development

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Another Brick in the Wall:

The role of the actinobacterial

cell wall in antibiotic resistance,

phylogeny and development

door

Lizah Tanja van der Aart Geboren te Haarlem, Nederland

7 augustus 1991

Proefschrift

ter verkrijging van

de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. C.J.J.M Stolker,

volgens besluit van het College voor Promoties te verdedigen op woensdag 20 maart 2019

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Promotiecommissie:

Promotoren: Prof. dr. G.P. van Wezel Prof. dr. T. Hankemeier Overige leden: Prof. dr. A.H. Meijer

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Contents:

Chapter 1 General Introduction

Chapter 2 Polyphasic classification of the gifted natural

product producer Streptomyces roseifaciens sp.

nov.

Chapter 3 High-resolution analysis of the peptidoglycan

composition in Streptomyces coelicolor

Chapter 4 The peptidoglycan composition of Kitasatospora

setae and Kitasatospora viridifaciens is highly

modified during sporulation.

Appendix 1

Chapter 5 Substrate inhibition of VanA by D-alanine

reduces vancomycin resistance in a VanX-dependent manner.

Chapter 6 Structural and functional characterization of

the alanine racemase from Streptomyces

coelicolor A3(2)

Chapter 7 General Discussion

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