Cover Page
The following handle holds various files of this Leiden University dissertation:
http://hdl.handle.net/1887/68280
Author: Kamphuis, V.P.
Title: Multidimensional evaluation of cardiac hemodynamics and electrophysiology in
patients with congenital and acquired heart disease
Multidimensional evaluation of cardiac hemodynamics
and electrophysiology in patients with congenital
and acquired heart disease
© 2018 V.P. Kamphuis, Leiden, The Netherlands
All rights reserved. No part of this thesis may be reproduced, stored or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording or any information storage or retrieval system, without permission of the copyright owner.
ISBN: 978-94-6323-462-7
The research described in this thesis was supported by a grant of the Dutch Heart Foundation (DHF grant number 2013T091).
Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged.
The printing of this thesis was financially supported by Willem-Alexander kinderziekenhuis Leiden, Medis medical imaging systems B.V., Fysiologic ECG services B.V., Pie Medical Imaging B.V. Cover image: Intracardiac 4D flow MRI, made with LAVA (with thanks to Patrick de Koning), cover model: Daan Kamphuis
Back cover: Hook’s hut beach, Curaçao Printed by: Gildeprint, Enschede
Multidimensional evaluation of cardiac hemodynamics and
electrophysiology in patients with congenital
and acquired heart disease
Proefschrift
Ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op donderdag 31 januari 2019
klokke 16:15 uur door
Vivian Paola Kamphuis geboren te Willemstad, Curaçao
© 2018 V.P. Kamphuis, Leiden, The Netherlands
All rights reserved. No part of this thesis may be reproduced, stored or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording or any information storage or retrieval system, without permission of the copyright owner.
ISBN: 978-94-6323-462-7
The research described in this thesis was supported by a grant of the Dutch Heart Foundation (DHF grant number 2013T091).
Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged.
The printing of this thesis was financially supported by Willem-Alexander kinderziekenhuis Leiden, Medis medical imaging systems B.V., Fysiologic ECG services B.V., Pie Medical Imaging B.V. Cover image: Intracardiac 4D flow MRI, made with LAVA (with thanks to Patrick de Koning), cover model: Daan Kamphuis
Back cover: Hook’s hut beach, Curaçao Printed by: Gildeprint, Enschede
Multidimensional evaluation of cardiac hemodynamics and
electrophysiology in patients with congenital
and acquired heart disease
Proefschrift
Ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op donderdag 31 januari 2019
klokke 16:15 uur door
Vivian Paola Kamphuis geboren te Willemstad, Curaçao
Promotores: Prof. dr. N.A. Blom Prof. dr. W.A. Helbing
Co-promotor: Dr. A.A.W. Roest
Promotiecommissie: Prof. dr. M.J. Schalij Prof. dr. A. de Roos
Prof. dr. B.J.M. Mulder-van der Wall (Universiteit van Amsterdam) Dr. M. Carlsson (University of Lund, Sweden)
Dr. R.N. Planken (Universiteit van Amsterdam)
Promotores: Prof. dr. N.A. Blom Prof. dr. W.A. Helbing
Co-promotor: Dr. A.A.W. Roest
Promotiecommissie: Prof. dr. M.J. Schalij Prof. dr. A. de Roos
Prof. dr. B.J.M. Mulder-van der Wall (Universiteit van Amsterdam) Dr. M. Carlsson (University of Lund, Sweden)
Dr. R.N. Planken (Universiteit van Amsterdam)
Table of contents
Chapter 1 9 Part I 17 Chapter 2 19 Chapter 3 31 Chapter 4 45 Chapter 5 63 Part II 81 Chapter 6 83 Chapter 7 111 Chapter 8General introduction and thesis outline
Electrocardiographic variables reflecting cardiac function Electrocardiographic characteristics before and after correction of right-sided congenital heart defects and its relation to prognosis. J Electrocardiol. 2018. doi: 10.1016/j.jelectrocard.2018.10.001. [Epub ahead of print]
Normal values of the ventricular gradient and QRS-T angle, derived from the pediatric electrocardiogram.
J Electrocardiol. 2018 May - Jun;51(3):490-495
Electrical remodeling after percutaneous atrial septal defect closure in pediatric and adult patients.
Submitted for publication
Electrocardiographic detection of right ventricular pressure overload in patients with suspected pulmonary hypertension.
J Electrocardiol. 2014 Mar-Apr;47(2):175-82.
4D flow MRI-derived cardiac flow and function: validation and clinical utility
Unravelling cardiovascular disease using four dimensional flow cardiovascular magnetic resonance.
Int J Cardiovasc Imaging. 2017 Jul;33(7):1069-1081.
Direct assessment of tricuspid regurgitation by 4D flow CMR in a patient with Ebstein’s anomaly.
Eur Heart J Cardiovasc Imaging. 2018 May;19(5): 587-588
Bi-ventricular vortex ring formation corresponds to regions of highest intra-ventricular viscous energy loss in a Fontan patient: analysis by 4D flow MRI.
Int J Cardiovasc Imaging. 2018 Mar;34(3):441-442.
In-scan and scan-rescan assessment of LV in- and outflow volumes by 4D flow MRI versus 2D planimetry.
J Magn Reson Imaging. 2018 Feb;47(2):511-522
Automated cardiac valve tracking for flow quantification with four-dimensional flow MRI
Radiology. 2018. doi: 10.1148/radiol.2018180807. [Epub ahead of print]
133 Part III 161 Chapter 9 163 Chapter 10 191 Chapter 11 221 Chapter 12 239 Chapter 13 257 Chapter 14 267 Appendices
4D flow MRI-derived novel determinants of intraventricular hemodynamics
Scan-rescan reproducibility of diastolic left ventricular kinetic energy, viscous energy loss and vorticity assessment using 4D flow MRI: analysis in healthy subjects.
Int J Cardiovasc Imaging. 2018 Jun;34(6):905-920.
Disproportionate intraventricular viscous energy loss in Fontan patients: analysis by 4D flow MRI.
Eur Heart J Cardiovasc Imaging 2018 doi: 10.1093/ehjci/jey096. [Epub ahead of print]
Intraventricular vorticity is associated with viscous energy loss and kinetic energy from 4D flow MRI in healthy subjects and Fontan patients.
Submitted for publication
Dobutamine-induced increase in intracardiac kinetic energy, energy loss and vorticity is inversely related to VO2max in Fontan patients.
Submitted for publication
General discussion and conclusions
Table of contents
Chapter 1 9 Part I 17 Chapter 2 19 Chapter 3 31 Chapter 4 45 Chapter 5 63 Part II 81 Chapter 6 83 Chapter 7 111 Chapter 8General introduction and thesis outline
Electrocardiographic variables reflecting cardiac function Electrocardiographic characteristics before and after correction of right-sided congenital heart defects and its relation to prognosis. J Electrocardiol. 2018. doi: 10.1016/j.jelectrocard.2018.10.001. [Epub ahead of print]
Normal values of the ventricular gradient and QRS-T angle, derived from the pediatric electrocardiogram.
J Electrocardiol. 2018 May - Jun;51(3):490-495
Electrical remodeling after percutaneous atrial septal defect closure in pediatric and adult patients.
Submitted for publication
Electrocardiographic detection of right ventricular pressure overload in patients with suspected pulmonary hypertension.
J Electrocardiol. 2014 Mar-Apr;47(2):175-82.
4D flow MRI-derived cardiac flow and function: validation and clinical utility
Unravelling cardiovascular disease using four dimensional flow cardiovascular magnetic resonance.
Int J Cardiovasc Imaging. 2017 Jul;33(7):1069-1081.
Direct assessment of tricuspid regurgitation by 4D flow CMR in a patient with Ebstein’s anomaly.
Eur Heart J Cardiovasc Imaging. 2018 May;19(5): 587-588
Bi-ventricular vortex ring formation corresponds to regions of highest intra-ventricular viscous energy loss in a Fontan patient: analysis by 4D flow MRI.
Int J Cardiovasc Imaging. 2018 Mar;34(3):441-442.
In-scan and scan-rescan assessment of LV in- and outflow volumes by 4D flow MRI versus 2D planimetry.
J Magn Reson Imaging. 2018 Feb;47(2):511-522
Automated cardiac valve tracking for flow quantification with four-dimensional flow MRI
Radiology. 2018. doi: 10.1148/radiol.2018180807. [Epub ahead of print]
133 Part III 161 Chapter 9 163 Chapter 10 191 Chapter 11 221 Chapter 12 239 Chapter 13 257 Chapter 14 267 Appendices
4D flow MRI-derived novel determinants of intraventricular hemodynamics
Scan-rescan reproducibility of diastolic left ventricular kinetic energy, viscous energy loss and vorticity assessment using 4D flow MRI: analysis in healthy subjects.
Int J Cardiovasc Imaging. 2018 Jun;34(6):905-920.
Disproportionate intraventricular viscous energy loss in Fontan patients: analysis by 4D flow MRI.
Eur Heart J Cardiovasc Imaging 2018 doi: 10.1093/ehjci/jey096. [Epub ahead of print]
Intraventricular vorticity is associated with viscous energy loss and kinetic energy from 4D flow MRI in healthy subjects and Fontan patients.
Submitted for publication
Dobutamine-induced increase in intracardiac kinetic energy, energy loss and vorticity is inversely related to VO2max in Fontan patients.
Submitted for publication
General discussion and conclusions
