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Author: Beyranvand Nejad, E.

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Chemotherapy Antibody-based therapy

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Antibody-based therapy Cytokine-based therapy

Induce tumor cell apoptosis

Enhance intratumoral vascular permeability

Concurrent with

Immunotherapy

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Immune checkpoint inhibitors

s e n i k o t y c y r o t a m m a l f n i -i t n A C D CD4+ Pro-inflammatory cytokines CD8+ M2 macrophage

Sentitize tumor cells to killing:

Chemotherapy

Tumor cell

Tregs Costimulatory molecules

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