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The thyrotropin receptor in thyroid carcinoma Hovens, G.C.J.

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The thyrotropin receptor in thyroid carcinoma

Hovens, G.C.J.

Citation

Hovens, G. C. J. (2008, September 18). The thyrotropin receptor in thyroid carcinoma.

Retrieved from https://hdl.handle.net/1887/13103

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/13103

Note: To cite this publication please use the final published version (if applicable).

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The Thyrotropin Receptor In Thyroid Carcinoma

Guido C.J. Hovens

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The Thyrotropin Receptor In Thyroid Carcinoma Dit onderzoek is financieel ondersteund door KWF KANKER BESTRIJDING

(UL 2001 -2568)

©2008 Guido C.J. Hovens Print: Ponsen & Looijen BV

De druk van dit proefschri werd financieel ondersteund door KWF KANKER

BESTRIJDING, Ipsen, J.E. Jurriaanse Schng, Pfizer en Novars Oncology

ISBN 978-90-6464-280-7

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The Thyrotropin Receptor In Thyroid Carcinoma

Proefschri

ter verkrijging van

de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr.dr. P. F. van der Heijden,

volgens besluit van het College voor Promoes te verdedigen op donderdag 18 september 2008

klokke 13.45 uur

door

Guido Chrisaan Johannes Hovens

geboren te Tegelen In 1976.

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Promoecommissie

Promotores:

Copromotor:

Referent:

Overige leden:

Prof.dr. J.W.A. Smit Prof.dr. J.A. Romijn Dr. H.B.J. Karperien

Dr. T.P.Links (Universitair Medisch Centrum Groningen) Prof.dr. J. Morreau

Prof.dr. C.W.G.M. Lowik Prof.dr. J. Kievit Prof.dr. H. Pijl

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Ignoran quem portum petat nullus suus ventus est

If one does not know to which port one is sailing, no wind is favorable.

Lucius Annaeus Seneca (4BC - AD65)

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General Introducon

Associaons of Serum Thyrotropin Concentraons with Recurrence and Death in Differenated Thyroid Cancer Treatment of the follicular thyroid carcinoma cell-line FTC-133 with Troglitazone and Lovastan synergiscally in- creases expression of G1 transion inhibitors and induces re-differenaon

Superior Thyrotropin Receptor Binding and Acvaon of a Novel, Modified, Single Chain Thyroid Smulang Hormone A Bio-Luminescence Assay for Thyrotropin Receptor

Anbodies Predicts Serum Thyroid Hormone Levels in Paents with de novo Graves’ Disease

Inducon of Smulang Thyrotropin Receptor Anbodies aer Radioiodine Therapy for Toxic Mulnodular Goiter and Graves Disease Measured with a Novel Bio-assay.

Summary and Discussion Samenvang en Discussie References

Nawoord Curriculum Vitae List of Publicaons

9 27

41

53

69

81

91 105 121 147 151 155 Chapter 1

Chapter 2

Chapter 3

Chapter 4

Chapter 5

Chapter 6

Chapter 7 Chapter 8

Contents

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