The pathophysiology of MuSK myasthenia gravis

Here, we show that pathogenic IgG4 antibodies to MuSK bind to a structural epitope in the first Ig-like domain of MuSK, prevent binding between MuSK and LRP4 and inhibit

To investigate epitope spreading and the association with disease severity, reactivity patterns and treatment responsiveness in MuSK MG, we mapped and independently confirmed

94,95 We studied the epidemiology of myasthenia gravis subtypes, the proportion of MuSK Ab+ MG in patients with generalised AChR Ab- MG in a well-defined region in the

Title: Autoimmune myasthenia gravis the impact of heterogeneous patterns of muscle weakness on outcome measures and diagnosis. Issue

Wij hebben deze groep als hoog risico geclassificeerd gezien het aantal case reports en het aantal Lareb/ WHO -meldingen waarbij verergering van MG en myasthene crisis is

Monospecific antibodies against AChR (B2) or MuSK (B1) are unable to cross-link both an- tigens. C) Sera from 31 MuSK-MG patients or eleven healthy controls were incubated with

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electrophysiological deficits which both contribute to reduction of the safety factor of neuromuscular transmission: 1) the EPPs become small due to the loss of a proportion of