• No results found

Cover Page The handle http://hdl.handle.net/1887/45230

N/A
N/A
Info
Downloaden
Protected

Academic year: 2021

Share "Cover Page The handle http://hdl.handle.net/1887/45230"

Copied!
9
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Download het nu ( 9 pagina )

Hele tekst

(1)

Cover Page

The handle http://hdl.handle.net/1887/45230 holds various files of this Leiden University dissertation

Author: Jing Tu

Title: Mesoporous silica nanoparticle-based protein delivery systems for biomedical applications

Issue Date: 2016-12-21

(2)

Mesoporous Silica Nanoparticle-Based Protein Delivery Systems for Biomedical Applications

JING TU

(3)

2

Doctoral Thesis, Leiden University, 2016 Cover design: Jing Tu

Printed by GVO drukkers & vormgevers B.V. Ede

ISBN: 978-94-6332-119-8

(4)

Mesoporous Silica Nanoparticle-based protein delivery systems for biomedical applications

Proefschrift

ter verkrijging van

de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus Prof. mr. C.J.J.M. Stolker,

volgens het besluit van het College voor Promoties te verdedigen op woensdag 21 december 2016

klokke 10:00 uur

door

涂晶

Jing Tu

Geboren op 11 Oktober te Wuhan, China in 1985

(5)

Promotiecomissie

Promotor: Prof. dr. A. Kros Overige leden:

Prof. dr. J. Brouwer (voorzitter) Prof. dr. J. Bouwstra (secretaris) Prof. dr. J.I. Zink

1

Dr. S. Bonnet

Dr. C.F. van Nostrum

2

1 Dept. Chemistry & Biochemistry, UCLA, USA

2 Dept. Pharmaceutics, Utrecht University, the Netherlands

(6)

To my family

(7)

6

(8)

Table of Contents

Chapter I

General Introduction 9 Chapter II

Mesoporous Silica Nanoparticles with Large Pores for the Encapsulation and Release of Proteins 27 Chapter III

Mesoporous Silica Nanoparticle-Coated Microneedles for Intradermal Delivery of Ovalbumin 49 Chapter IV

Membrane Fusion Mediated Intracellular Delivery of Lipid Bilayer Coated Mesoporous Silica Nanoparticles 71 Chapter V

Lipid Bilayer-Coated Mesoporous Silica Nanoparticles Carrying Bovine Hemoglobin as an Erythrocyte Mimic 97 Chapter VI

Estimation of Single Mesoporous Silica Nanoparticle’s Weight 121 Chapter VII

Summary and Perspectives 129

Curriculum vitae 141

List of publications 142

(9)

Referenties

Download het nu ( PDF - 9 pagina - 238.70 KB )

GERELATEERDE DOCUMENTEN

Cover Page The handle http://hdl.handle.net/1887/45230

(c) mean MSN size and standard deviation (SD) calculated by the NTA software; (d) NTA particle concentration (10 8 particles/mL) as a function of particle concentration

Cover Page The handle http://hdl.handle.net/1887/45230

These MSNs with their large surface area and optimal dimensions, provide a scaffold with a high encapsulation efficiency and controllable release profiles for a variety of

Cover Page The handle http://hdl.handle.net/1887/45230

Zoals ook met eiwitten het geval is, zal voor de afgifte aflevering van siRNA in cellen een aantal hordes genomen moeten worden aangezien siRNAs niet membraan-permeabel zijn

Cover Page The handle http://hdl.handle.net/1887/45230

She presented the 14 th European Symposium on Controlled Drug Delivery, with a poster presentation named “Coiled-coil Forming Peptides Enhance Intracellular Delivery by

Cover Page The handle http://hdl.handle.net/1887/45230

Mesoporous silica nanoparticles (MSNs) can be used as protein delivery carriers due to their unique properties, namely biocompatibility, chemical inertness, large

Cover Page The handle http://hdl.handle.net/1887/41202 holds various files of this Leiden University dissertation Author: Hamers, Adrian Sven Title: Hierarchical systems Issue Date: 2016-06-21

Author: Hamers, Adrian Sven Title: Hierarchical systems Issue Date: 2016-06-21..

Cover Page The handle http://hdl.handle.net/1887/41202 holds various files of this Leiden University dissertation Author: Hamers, Adrian Sven Title: Hierarchical systems Issue Date: 2016-06-21

As mentioned in Section 4.1, the hierarchical configuration considered in this work can be ap- plied to planetary systems consisting of a planet+moon system (binary A) orbiting

Cover Page The handle http://hdl.handle.net/1887/41202 holds various files of this Leiden University dissertation Author: Hamers, Adrian Sven Title: Hierarchical systems Issue Date: 2016-06-21

6 Secular dynamics of hierarchical multiple systems composed of nested binaries, with an arbitrary number of bodies and arbitrary hierarchical structure 231 6.1