Adoptive immunotherapy for viral infections after allogeneic stem cell transplantation
Zandvliet, M.L.
Citation
Zandvliet, M. L. (2011, March 22). Adoptive immunotherapy for viral infections after allogeneic stem cell transplantation. Retrieved from https://hdl.handle.net/1887/16641
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden Downloaded
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Adoptive immunotherapy for viral infections after
allogeneic stem cell transplantation
Maarten L. Zandvliet
Adoptive immunotherapy for viral infections after allogeneic stem cell transplantation
© 2011 Maarten Zandvliet, Leiden.
No part of this thesis may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording or any information storage or retrieval system, without permission of the copyright owner.
ISBN/EAN: 978-90-9026045-7
Graphic design: In Zicht Grafisch Ontwerp, Arnhem, www.promotie-inzicht.nl Anthe Zandvliet, Amsterdam
Printing: Ipskamp Drukkers BV, Enschede
The printing of this thesis was financially supported by AZL Onderzoeks- en Ontwikkelingskrediet Apotheek.
Adoptive immunotherapy for viral infections after allogeneic stem cell transplantation
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op dinsdag 22 maart 2011
klokke 13:45 uur door
Maarten Laurens Zandvliet geboren te Alkmaar
in 1979
Promotiecommissie Promotores
Prof. Dr. H.-J. Guchelaar Prof. Dr. J.H.F. Falkenburg Co-promotor
Dr. P. Meij Overige leden
Prof. Dr. R.M. Egeler Prof. Dr. C.J.M. Melief
Prof. Dr. G.J. Ossenkoppele (VU medisch centrum, Vrije Universiteit Amsterdam)
Contents
Chapter 1 General introduction and aim of the thesis 9 Submitted
Chapter 2 Detailed analysis of IFNγ response upon activation permits 35 efficient isolation of cytomegalovirus-specific CD8+ T cells for adoptive immunotherapy
J Immunother 32: 513-523, 2009
Chapter 3 Coordinated isolation of CD8+ and CD4+ T cells recognizing 57 a broad repertoire of cytomegalovirus pp65 and IE1 epitopes for highly specific adoptive immunotherapy
Cytotherapy 12: 933-944, 2010
Chapter 4 Combined CD8+ and CD4+ adenovirus hexon-specific T-cells 77 associated with viral clearance after stem cell transplantation
as treatment for adenovirus infection Haematologica 95: 1943-1951, 2010
Chapter 5 Simultaneous isolation of CD8+ and CD4+ T cells specific for 99 multiple viruses for broad antiviral immune reconstitution after allogeneic stem cell transplantation
J Immunother, in press
Chapter 6 Efficiency and mechanism of antigen-specific CD8+ T cell activation 123 using synthetic long peptides
Submitted
Chapter 7 Treatment of refractory cytomegalovirus reactivation after 147 allogeneic stem cell transplantation with in vitro generated cytomegalovirus pp65-specific CD8+ T cell lines
Submitted
Chapter 8 Summary 163
Chapter 9 General discussion 173
Nederlandse samenvatting 185
List of publications 197
List of abbreviations 199
Nawoord 201
Curriculum Vitae 203
