Cover Page
The handle http://hdl.handle.net/1887/45778 holds various files of this Leiden University dissertation
Author: Korndewal, Marjolein
Title: Consequences of congenital cytomegalovirus infection in early childhood
Issue Date: 2017-01-24
Consequencesofcongenital cytomegalovirusinfection
inearlychildhood
MarjoleinKorndewal
Consequencesofcongenitalcytomegalovirusinfectioninearlychildhood
PhDThesis,UniversityofLeiden,TheNetherlands
ISBN:978Ͳ94Ͳ6332Ͳ127Ͳ3
Coverdesign:MarijnVinkandBobEmbregts,AsuraMotionDesign,Zeist,theNetherlands
Printing:GVOdrukkers&vormgevers,Ede,theNetherlands
ThepublicationofthisthesiswasfinanciallysupportedbytheLeidenUniversityMedical
CenterandtheNationalInstituteforPublicHealthandtheEnvironment.
©2016M.J.Korndewal
Allrightsarereserved.Nopartofthispublicationmaybereproduced,storedinaretrieval
systemortransmittedinanyformorbyanymeans,electronic,mechanical,photocopying,
recordingorotherwise,withoutpriorpermissionoftheauthororthecopyrightͲowning
journalsandthepublishersforpreviouslypublishedchapters.
Consequences of congenital cytomegalovirus infection
in early childhood
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op dinsdag 24 januari 2017
klokke 15.00 uur door
MarjoleinJolandaKorndewal
geboren te Baarn
in 1982
Promotores
dhr.prof.dr.A.C.M.Kroes
mw.prof.dr.A.M.OudesluysͲMurphy
Copromotores
mw.dr.A.C.T.M.Vossen
mw.dr.H.E.deMelker (RijksinstituutvoorVolksgezondheidenMilieu)
Promotiecommissie
dhr.prof.dr.E.H.H.M.Rings
dhr.prof.dr.F.W.Dekker
dhr.prof.dr.J.H.M.Frijns
mw.prof.dr.E.A.M.Sanders(UniversiteitUtrecht)
dhr.dr.J.L.Murk (UniversiteitUtrecht)
Contents
Chapter1 Generalintroduction 7
Chapter2 CytomegalovirusinfectionintheNetherlands:seroprevalence,risk 41
factorsandimplications
Chapter3 Diseaseburdenofcongenitalcytomegalovirusinfectionatschool 57
entryage:studydesign,participationrateandbirthprevalence
Chapter4 LongͲtermimpairmentattributabletocongenitalcytomegalovirus 71
infection
Chapter5 Congenitalcytomegalovirusinfection:childdevelopment,quality 91
oflifeandimpactondailylife
Chapter6 Healthcarecostsattributabletocongenitalcytomegalovirusinfection 109
Chapter7 Generaldiscussion 131
Addendum Summary 155
Samenvatting 161
Abbreviations 167
Publications 169
CurriculumVitae 171
Dankwoord 173
