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Transcriptome profiling of infectious diseases and cancer in zebrafish Ordas, A.K.

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Transcriptome profiling of infectious diseases and cancer in zebrafish

Ordas, A.K.

Citation

Ordas, A. K. (2010, June 29). Transcriptome profiling of infectious diseases and cancer in zebrafish. Retrieved from https://hdl.handle.net/1887/15734

Version: Not Applicable (or Unknown)

License: Leiden University Non-exclusive license Downloaded from: https://hdl.handle.net/1887/15734

Note: To cite this publication please use the final published version (if applicable).

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Transcriptome profiling of infectious diseases and cancer in zebrafish

PROEFSCHRIFT

ter verkrijging van

de graad van Doctor aan de Universiteit Leiden,

op gezag van de Rector Magnificus prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties

te verdedigen op dinsdag 29 juni 2010 klokke 10:00 uur

door

Anita Katalin Ordas

geboren te Szeged, Hungary in 1980

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Promotiecommissie

Promotor: Prof. dr. H.P. Spaink Co-promotor: Dr. A.H. Meijer Overige leden: Prof. dr. C.J. ten Cate

Prof. dr. J. den Hertog

Prof. dr. J. Memelink

Prof. dr. B. van de Water

Prof. dr. N.S. Foulkes (University of Heidelberg) Dr. M. Mink (University of Szeged)

ISBN: 978-90-8570-579-6

Printed by Wöhrmann Print Service, Zutphen

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Go where the science takes you

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Contents

Chapter 1 7

General introduction

Chapter 2 29

Deep sequencing of the zebrafish transcriptome response to mycobacterium infection

Chapter 3 57

Deep sequencing of the innate immune transcriptomic response of zebrafish embryos to Salmonella infection

Chapter 4 77

MicroRNA expression during bacterial infections in zebrafish

Chapter 5 115

Liver tumor-related microRNA expression is conserved between zebrafish and human

Chapter 6 143

Summary and General discussion

Samenvatting 151

Összefoglaló 159

Curriculum vitae 165

List of publications 166

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