University of Groningen
Neuromodulation and depression van Belkum, Sjoerd Marten
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Publication date: 2018
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van Belkum, S. M. (2018). Neuromodulation and depression. Rijksuniversiteit Groningen.
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Neuromodulation and Depression
Sjoerd Marten van BelkumVan Belkum, SM
Neuromodulation and Depression ISBN: 978-94-034-0996-2
ISBN: 978-94-034-0995-5 (electronic version) Cover photograph: S. Rienstra
Cover design and thesis layout: S.M. van Belkum Printed via: Postmasters Groningen / Uitgeverij Palmslag © 2018 - Sjoerd M. van Belkum
All rigths are reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, mechanically, by photocopying, recording or otherwise, withouth the written permission of the author.
Financial support for the initial research project was granted by UMCG Innovation Fund, project U-11-221, and Fonds NutvsOhra, project 1103-068. Financial support in printing this thesis was kindly provided by: Research School of Behavioural and Cognitive Neuroscience and Rijksuniversiteit Groningen.
Neuromodulation and Depression
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 17 oktober 2018 om 14.30 uur
door
Sjoerd Marten van Belkum geboren op 3 maart 1986
Promotores
Prof. dr. R.A. Schoevers Prof. dr. A. Aleman
Copromotores Dr. E.M. Opmeer Dr. M.K. de Boer
Beoordelingscommissie Prof. dr. N.J.A. van der Wee Prof. dr. W.A. Nolen
Prof. dr. F. Padberg
Table of Contents
Chapter 1 General introduction 8
Part 1: Effects of tPEMF and related neuromodulation devices
Chapter 2 Non-invasive neuromodulation as a new therapeutic strategy in the management of functional somatic symptoms
24 Chapter 3 Treatment of depression with low strength transcranial
pulsed electromagnetic fields: a mechanistic point of view 50
Part 2: Quantifying treatment resistance in depression
Chapter 4 Validity of the Maudsley Staging Method in predicting treatment resistant depression outcome using the Netherlands Study of Depression and Anxiety
68
Part 3: A novel treatment for MDD?
Chapter 5 No antidepressive effects of transcranial pulsed electromagnetic fields for treatment resistant depression – a replication randomized controlled trial
92 Chapter 6 Change in brain activation after transcranial pulsed
electromagnetic fields in treatment resistant depression 114
Chapter 7 Summary and general discussion 132
Nederlandse samenvatting 150
References 160
Dankwoord 194
