Referral patterns, prognostic models and treatment in soft tissue sarcomas
Seinen, Johanna Magda
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Publication date: 2018
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Seinen, J. M. (2018). Referral patterns, prognostic models and treatment in soft tissue sarcomas. Rijksuniversiteit Groningen.
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Referral patterns, prognostic models
and treatment in soft tissue sarcomas
J.M. Seinen
Referral patterns, prognostic models and treatment in soft tissue sarcomas PhD thesis University Medical Center Groningen, the Netherlands
ISBN 9789463233262 Copyright © 2018 J.M. Seinen
All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, without prior written permission from the author
Layout: Gildeprint Drukkerijen Cover design: Enrique Molina Campos Printed by: Gildeprint Drukkerijen
Referral patterns, prognostic models
and treatment in soft tissue sarcomas
proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op maandag 10 september 2018 om 12.45 uur
door
Johanna Magda Seinen
geboren op 4 maart 1985 te Delfzijl
Prof.dr. J.V.M. Bovée Prof.dr. C. Verhoef Prof. dr. J.Th.M. Plukker
Paranimfen
Nynke Dijk Katharina Löhner
Contents
Chapter 1. General introduction 9
Part I Diagnosis and referral patterns
Chapter 2. Diagnosis and referral pattern of soft tissue sarcoma
patients 19
Chapter 3. Delays in the management of retroperitoneal sarcomas 27
Part II Prognostic markers and biomarkers
Chapter 4. Prognostic models and the role of biomarkers 41 Chapter 5. Prognostic value of proliferation in soft tissue
sarcomas: a new look at an old measure 53
Part III Isolated limb perfusion
Chapter 6. Isolated limb perfusion of soft tissue sarcomas: a
comprehensive review of literature 75 Chapter 7. Fractures after multimodality treatment of soft tissue
sarcomas with isolated limb perfusion and radiation; likely to occur and hard to heal
101
Part IV Angiosarcoma
Chapter 8. Angiosarcoma 125
Chapter 9. Radiation-associated angiosarcoma after breast cancer: High recurrence rate and poor survival despite surgical treatment with R0 resection
131
Part V Desmoid type fibromatosis
Chapter 10. Desmoid type fibromatosis 149
Chapter 11. Four different treatment strategies in desmoid type
fibromatosis: A systematic review 155
Chapter 12. Future perspectives 177
Appendix Samenvatting 191 Summary 199 Curriculum vitae 207 PhD portfolio 209 Dankwoord 215
