Citation
Kralingen, S. van. (2011, June 23). Pharmacokinetics and/or
pharmacodynamics of propofol, atracurium and cefazolin in morbidly obese patients. Retrieved from https://hdl.handle.net/1887/17732
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Pharmacokinetics and/or pharmacodynamics of propofol, atracurium and cefazolin in morbidly obese patients
Simone van Kralingen
The printing of this thesis was financed by the section Anaesthesiology, Intensive Care and Pain Medicine of the St. Antonius Hospital, Nieuwegein, The Netherlands
Cover design: iStockphoto.com
Lay-out and printing: Gildeprint Drukkerijen - Enschede, The Netherlands ISBN 978-94-6108-166-7
© 2011 Simone van Kralingen, Amsterdam. All rights reserved. No parts of this publication may be reproduced, stored in a retrieval system of any system of any nature, or transmitted in any part or by any means without the prior written permission of the holder of the copyright.
Pharmacokinetics and/or pharmacodynamics of propofol, atracurium and cefazolin in morbidly obese patients
Proefschrift
Ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van de Rector Magnificus prof. mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op donderdag 23 juni 2011
klokke 11.15 uur
door
Simone van Kralingen geboren te Hilversum in 1977
St. Antonius Ziekenhuis, Nieuwegein Dr. B. van Ramshorst
St. Antonius Ziekenhuis, Nieuwegein Overige leden: Prof. dr. M. Danhof
Leiden / Amsterdam Center for Drug Research, LACDR Prof. dr. A.P. IJzerman
Leiden / Amsterdam Center for Drug Research, LACDR Prof. dr. A. Dahan
Leids Universitair Medisch Centrum, LUMC Prof. dr. H.J. Guchelaar
Leids Universitair Medisch Centrum, LUMC Prof. dr. J.T.A. Knape
Universitair Medisch Centrum Utrecht, UMCU
Aan Rutger Aan mijn ouders
Contents
Section I General introduction
Chapter 1 Pharmacokinetics and/or pharmacodynamics 11 of propofol, atracurium and cefazolin in morbidly
obese patients
Chapter 2 Scope and intent of the investigations 31 Section II Propofol in morbidly obese patients
Chapter 3 Comparative evaluation of propofol 350 mg and 45 200 mg for induction of anaesthesia in morbidly
obese patients: a randomised double blind pilot study Chapter 4 Maintenance of anaesthesia in morbidly obese patients 61
using propofol with continuous BIS-monitoring:
a comparison of propofol-remifentanil and propofol- epidural anaesthesia
Chapter 5 Population pharmacokinetics and pharmacodynamics 85 of propofol in morbidly obese patients
Section III Atracurium in morbidly obese patients
Chapter 6 Comparative evaluation of atracurium dosed on 115 ideal body weight versus total body weight in morbidly obese patients
Section IV Cefazolin in morbidly obese patients
Chapter 7 Pharmacokinetics and protein binding of cefazolin 133 in morbidly obese patients
Samenvatting (Synopsis in Dutch) 175
Nawoord (Epilogue in Dutch) 195
Curriculum Vitae (in Dutch) 199
List of publications 201
