Cover Page
The following handle holds various files of this Leiden University dissertation:
http://hdl.handle.net/1887/59463
Author: Narayen, I.C.
Title: Neonatal screening with pulse oximetry
Issue Date: 2017-11-22
NEONATAL SCREENING WITH PULSE OXIMETRY
NEONATAL SCREENING WITH PULSE OXIMETRY
© 2017 I.C. Narayen, Leiden, the Netherlands
All rights reserved. No part of this thesis may be reproduced, stored or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording or any information storage or retrieval system, without permission of the copyright owner.
ISBN: 978-94-6233-781-7
Cover and layout: Gildeprint, Enschede Cover photo: Siryl van Poppel Printing: Gildeprint, Enschede
The research described in this thesis was financially supported by Medtronic, Stichting Harte- kind, ZonMw, Leiden University Foundation, and Stichting Gratama.
The printing of this thesis was financially supported by: Willem Alexander Children’s Hospi-
tal, Chiesi, Chipsoft, Department of Obstetrics (Leiden University Medical Center), Dräger
Nederland, Vygon, Masimo. Financial support by the Dutch Heart Foundation for the publica-
tion of this thesis is gratefully acknowledged
NEONATAL SCREENING WITH PULSE OXIMETRY
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties ter verdedigen op woensdag 22 november 2017
klokke 15.00 uur
door
Ilona Christina Narayen geboren te Zoetermeer
in 1989
Promotor: Prof. dr. N.A. Blom Copromotor: Dr. A.B. te Pas
Leden promotiecommissie: Prof. Dr. E. Lopriore Prof. Dr. J.M.M. van Lith
Prof. A.K. Ewer (University of Birmingham, UK)
Dr. S.A.B. Clur (University of Amsterdam, the Netherlands)
VOOR JULIE
TABLE OF CONTENTS
Preface 9
Chapter 1 General Introduction 15
Chapter 2 Aspects of pulse oximetry screening for critical congenital heart defects: when, how and why?
25
Chapter 3 Adapted protocol for pulse oximetry screening for congenital heart defects in a country with home births
41
Chapter 4 Pulse oximetry screening for critical congenital heart disease after home birth and early discharge
49
Chapter 5 Accuracy of pulse oximetry screening for critical congenital heart defects after home birth and early postnatal discharge
63
Chapter 6 Cost-effectiveness analysis of pulse oximetry screening for critical congenital heart defects in a setting with home births and short postnatal stay after in-hospital delivery
81
Chapter 7 Maternal acceptability of pulse oximetry screening at home after home birth or very early discharge
93
Chapter 8 Low signal quality pulse oximetry measurements in newborn infants are reliable for oxygen saturation but underestimate heart rate
101
Chapter 9 General Discussion 115
Chapter 10 Summary
Nederlandse samenvatting
133
Chapter 11 List of Abbreviations 149
Publications 151
Curriculum Vitae 155
Dankwoord 157
