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VU Research Portal

Targetable genetic signatures of immune evasion in lymphoma

Roemer, M.G.M.

2017

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citation for published version (APA)

Roemer, M. G. M. (2017). Targetable genetic signatures of immune evasion in lymphoma.

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Table of contents

Chapter 1 General Introduction 7

1.1. The Germinal Center 8

1.2. Non-Hodgkin lymphomas - DLBCL and LBCL subtypes 9 1.3. Hodgkin lymphoma 13

1.4. Role of the immune system in lymphoid malignancies 15

1.5. Immune checkpoint blockade in lymphoid malignancies 19

1.6. Outline and aims of this thesis 20

Chapter 2 Targetable genetic features of primary testicular and primary central nervous system lymphomas 25

Chapter 3 Recurrent genetic alterations of CD274 (PD-L1) and PDCD1GL2 (PD-L2) in T-cell/histiocyte rich large B-cell lymphoma 49

Chapter 4 B-cell and classical Hodgkin lymphomas associated with immunodeficiency 57

Chapter 5 PD-L1 and PD-L2 genetic alterations define classical Hodgkin lymphoma and predict outcome 75

Chapter 6 Chromosome 9p24.1/PD-L1/PD-L2 alterations and PD-L1 expression and treatment outcomes in patients with classical Hodgkin lymphoma treated with Nivolumab (PD-1 blockade) 91

Chapter 7 Classical Hodgkin lymphoma with reduced β2M/MHC class I expression is associated with inferior outcome independent of 9p24.1 status 101

Chapter 8 Discussion 115

8.1. Targetable genetic features of LBCLs 116

8.2. Chromosome 9p24.1 alterations in lymphoid malignancies 120 8.3. Immune evasion in Hodgkin lymphoma 125

8.4. Conclusions 130 Chapter 9 Appendices 135 9.1. Summary 136 9.2. Nederlandse samenvatting 141 9.3. Acknowledgements 148 9.4. List of publications 155

9.5. About the author 157

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