• No results found

VU Research Portal

N/A
N/A
Protected

Academic year: 2021

Share "VU Research Portal"

Copied!
5
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Hele tekst

(1)

VU Research Portal

Loss-of-function shRNA screens to identify mechanisms of PARP inhibitor resistance

in BRCA1-mutated mouse mammary tumors

Xu, G.

2016

document version

Publisher's PDF, also known as Version of record

Link to publication in VU Research Portal

citation for published version (APA)

Xu, G. (2016). Loss-of-function shRNA screens to identify mechanisms of PARP inhibitor resistance in

BRCA1-mutated mouse mammary tumors.

General rights

Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain

• You may freely distribute the URL identifying the publication in the public portal ? Take down policy

If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.

E-mail address:

vuresearchportal.ub@vu.nl

(2)

Loss-of-function shRNA screens to identify

mechanisms of PARP inhibitor resistance in

BRCA1-mutated mouse mammary tumors

(3)

ISBN: 978-94-6295-302-4

Copyright by ©2015 by Guotai Xu. All rights reserved.

Cover design: Guotai Xu, Xuan Qu and Qing Xia.

The research described in this thesis was carried out at the division of

Molecular Oncology and the division of Molecular Pathology at the

Netherlands Cancer Institute in Amsterdam, The Netherlands.

Published by the Netherlands Cancer Institute.

(4)

VRIJE UNIVERSITEIT

Loss-of-function shRNA screens to identify mechanisms of

PARP inhibitor resistance in BRCA1-mutated mouse mammary tumors

ACADEMISCH PROEFSCHRIFT

ter verkrijging van de graad Doctor aan

de Vrije Universiteit Amsterdam,

op gezag van de rector magnificus

prof.dr. V. Subramaniam,

in het openbaar te verdedigen

ten overstaan van de promotiecommissie

van de Faculteit der Geneeskunde

op dinsdag 5 januari 2016 om 11.45 uur

in de aula van de universiteit,

De Boelelaan 1105

door

Guotai Xu

(5)

Referenties

GERELATEERDE DOCUMENTEN

b, Quantification of RAD51 foci in KB1P-G3 cells (with or without REV7 depletion) transfected with an empty vector (GFP) or vectors containing mouse or human

We observed this phenomenon by immunofluorescence of endogenous HELB in MEFs, where HELB loses its nuclear enrichment in cells that are undergoing DNA replication (Figure 6A and

In addition, we found that XRN2 loss also causes PARP inhibitor (PARPi) resistance of Brca1; p53-deficient mouse mammary tumor cells both in vitro and in vivo.. We aim

In particular, the groups of Jos Jonkers and Andre Nussenzweig found that loss of 53BP1 enhanced end resection at DSBs and restored BRCA1- independent HR,

In Chapter 2, we report that loss of REV7 (also known as MAD2L2) in mouse and human cells rescues CTIP-dependent end resection of DSBs in BRCA1- deficient

Consistent met de nieuwe rol van HELB als antagonist van resectie, leidt verlies van HELB ook tot gedeeltelijk herstel van HR en resistentie tegen PARP remming

Loss-of-function shRNA screens to identify mechanisms of PARP inhibitor resistance in BRCA1-mutated mouse mammary tumors..

Jaspers, Wendy Sol, Ariena Kersbergen, Andreas Schlicker, Charlotte Guyader, Guotai Xu, Lodewyk Wessels, Piet Borst, Jos Jonkers, Sven Rottenberg. PARP Inhibitors for Cancer