Cellular signaling in human cholesteatoma
Huisman, Margaretha Aleida
Citation
Huisman, M. A. (2007, January 24). Cellular signaling in human cholesteatoma. Retrieved
from https://hdl.handle.net/1887/9449
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the
Institutional Repository of the University of Leiden
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Cellular Signaling
in Human
Choles t eat oma
PROEFSCHRIFT
ter verkrijging van de graad van Doctor
aan de Univers iteit te L eiden,
op gez ag van de Rector Magnif icu s Dr. D. D. Breimer,
h oogl eraar in de f acu l teit der Wis ku nde en
Natu u rwetens ch ap p en en die der Genees ku nde,
vol gens b es l u it van h et Col l ege voor P romoties
te verdedigen op woens dag 2 4 janu ari 2 0 0 7
te kl okke 1 3 . 4 5 u u r
door
Margaretha Aleida Huisman
Geb oren te Deventer in 1 9 5 3
titelblad.p65 1 12 /5/2 0 0 6, 11:3 3 A M
Promotiecommissie
Promotor: Prof. Dr. J.J. Grote
Co- promotor: Dr. E . de Heer
Referent: Prof. Dr. C.J. Cornelisse
Overige leden: Prof. Dr. I r. J.H.M. F rijns
Prof. Dr. P.S. Hiemstra
T his study was performed at the department of
Otorhinolary ngology , Leiden University Medical Center, T he
Netherlands
titelblad.p65 2 12/5/2006, 11:33 AM
ISBN: 90-9021479-8
D e s i g n c o v e r : O K T O BE R v i s u e l e c o m m u n i c a t i e
P r i n t : G i l d e p r i n t D r u k k e r i j e n B. V .
Voor mijn ouders
Voor mijn k inderen
opdrachtpagina.p65 111 12/11/2006, 12:38 P M
opdrachtpagina.p65 112 12/11/2006, 12:38 PM
5 Contents
Chapter1: GeneralIntroduction p.7-20
Chapter2: Molecularpathways in human p.21-38 cholesteatoma
Chapter3: Cholesteatomaepithelium is characterized p.39-48 byincreasedexpression ofKi-67,p53and
p21,withminimalapoptosis.
Chapter4: Terminaldifferentiation andmitogen- p.49-58
cholesteatomaepithelium.
Chapter5: Sustainedextracellularsignal-regulated p.59-68 kinase 1/2mitogen-activatedprotein
p21expression in cholesteatomaepithelium.
Chapter6: p.69-78
differentiation in cholesteatomaepithelium
Chapter7: Human cholesteatomabehaves as achronic p.79-90
Chapter8: SummaryandGeneralDiscussion p.91-98
Nederlandse Samenvatting p.99-106
Curriculum Vitae p.107
Publications p.108
Nawoord p.109
List ofabbreviations p.110-111
contents.p65 5 12/5/2006, 11:31 AM
activatedprotein kinase signallingin human
kinase signalingis relatedto increased
Survivalsignallingandterminal
wound:the role oftransforminggrowth factor
β
6
