In Vivo flow and wall shear stress assessment in the carotid
artery with MRI
Box, F.M.A.
Citation
Box, F. M. A. (2007, September 13). In Vivo flow and wall shear stress assessment in the carotid artery with MRI. Retrieved from
https://hdl.handle.net/1887/12558
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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In Vivo Flow and Wall Shear Stress
Assessment in the Carotid Artery
with MRI
Frieke M.A. Box
ISBN: 9883242
ISBN/EAN: 978-90-9022046-8
In Vivo Flow and Wall Shear Stress Assessment in the Carotid Artery with MRI.
Frederike Maria Anna Box Proefschrift Universiteit Leiden Met samenvatting in het Nederlands
© by F.M.A. Box, except for the following chapters:
Chapter 2, 5 ,7: © Lippincott Williams & Wilkins, Inc.
Chapter 3: © Wiley-Liss, Inc.
No part of this thesis may be reproduced in any form by print, photocopy, in digital format or by any other means without prior written permission of the author Printed by Drukkerij Groen, Leiden, the Netherlands
In Vivo Flow and Wall Shear Stress
Assessment in the Carotid Artery
with MRI
In vivo bepaling van de bloeddoorstroming en
wandschuifspanning in de halsslagader met MRI
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op donderdag 13 september 2007 klokke 16.15 uur
door
Frederike (Frieke) Maria Anna Box geboren te Veldhoven
in 1964
Promotiecommissie Promotores:
Prof. dr. ir. J.H.C. Reiber Prof. dr. M.A. van Buchem Co-promotor:
Ir. R.J. van der Geest Referent:
Prof. dr. A.J. Rabelink Overige leden:
Prof. dr. J.A. Romijn
Prof. dr. ir. A.P.G. Hoeks (Universiteit Maastricht)
Financial support for chapter 5 was provided by Bristol Myers-Squibb, Princeton, New Jersey, USA
The study described in chapters 3-7 was supported by a grant of the Netherlands Heart Foundation Grant 2000.119.
Financial support for the publication of this thesis by the following organizations is gratefully acknowledged:
Stichting Beeldverwerking Leiden Foundation Imago (Oegstgeest) Netherlands Heart Foundation
Contents
1 Introduction 7
2 Automatic model-based contour detection and blood flow 19 quantification in small vessels with velocity encoded MRI
3 Reproducibility of wall shear stress assessment with 39 the paraboloid method in the internal carotid artery
with velocity encoded MRI in healthy young individuals
4 Differences in blood velocity profiles between young and 55 elderly healthy volunteers in the internal carotid artery;
a study with MRI
5 Pravastatin decreases wall shear stress and blood 69 velocity in the internal carotid artery without
affecting flow volume; results from the PROSPER MRI study.
6 Patient specific imaging for computational fluid 77 dynamical calculations with MRI
7 The influence of flow, vessel diameter and non- 97 Newtonian blood viscosity on the wall shear
stress in a carotid bifurcation model for unsteady flow.
8 Summary and Conclusions 125
9 Samenvatting en Conclusies 129
Publications 135
Curriculum Vitae 139
