Clinical proteomics in oncology : a passionate dance between science
and clinic
Noo, M.E. de
Citation
Noo, M. E. de. (2007, October 9). Clinical proteomics in oncology : a passionate dance
between science and clinic. Retrieved from https://hdl.handle.net/1887/12371
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the
Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/12371
Note: To cite this publication please use the final published version (if applicable).
Clinical Proteomics in
oncology:
A passionate dance between
science and clinic
Cover: L’etoile [La danseuse sur la scene] 1871, by Edgar Degas, Musee d’Orsay, Paris
© 2007, M.E. de Noo ISBN 978-90-9022-020-8
Printed by Optima Grafi sche Communicatie B.V. Rotterdam
This thesis is fi nancially supported by BIOMET, Farwick Groenspecialisten,Greiner, KCI Medical, LCS Systemen, Nycomed, Roche, Sanofi Aventis, Smith & Nephew Hoofddorp, Stichting ter bevordering van de Chirurgische Wetenschappen te Leiden, Tyco Healthcare
Clinical Proteomics in
oncology:
A passionate dance between
science and clinic
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van de rector Magnifi cus prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op dinsdag 9 oktober 2007 klokke 16.15 uur
door Mirre E. de Noo geboren te Enschede in 1978.
PROMOTIECOMMISSIE:
Promotores : Prof. Dr. A.M. Deelder Prof. Dr. R.A.E.M. Tollenaar
Referent: Dr. L. van ’t Veer (NKI-AVL, Amsterdam) Overige Leden: Prof. Dr. I.H.M. Borel Rinkes (UMC, Utrecht)
Prof. M.J. Duffy (St. Vincent’s University Hospital, Dublin) Dr. M. Frohlich
Prof. Dr. D.W. Hommes Dr. B.J.A. Mertens
Prof. Dr. C.J.H. van de Velde
Voor Han
Surgeons must be very careful When they take the knife Underneath their fi ne incisions Stirs the culprit–Life!
Emily Dickinson
CONTENTS
Chapter 1 Introduction 9
Chapter 2 Translational research in prognostic profi ling in colorectal cancer
Dig Surg 2005, 22:276-81
23
Chapter 3 Reliability of human serum protein profi les generated with C8 magnetic beads assisted MALDI-TOF mass spectrometry Anal Chem 2005, 77 (22):7232-41
35
Chapter 4 The use of serological protein profi les for the detection of colorectal cancer
Eur J Canc 2006, 42 (8):1068-76
55
Chapter 5 Mass spectrometry proteomic diagnosis; enacting the double cross validatory paradigm
J Comp Biol 2006, 13(9):1591-605
73
Chapter 6 MALDI-TOF serum protein profi les for the detection of breast cancer
Onkologie 2006, 29(11):501-6
97
Chapter 7 Validation of serological protein profi les for the detection of breast cancer
Submitted
111
Chapter 8 General Discussion: Current status and prospects of clinical proteomics studies on the detection of colorectal cancer: hopes and fears
World J Gastroenterol 2006, 12(41):6594-601
127
Chapter 9 Nederlandse samenvatting
Tijdschrift kanker 2006, 30 (4): 20-26r
145
Dankwoord 153
Curriculum vitae 157
List of publications 159
