Cellular senescence in vitro and organismal ageing
Maier, A.B.
Citation
Maier, A. B. (2008, December 11). Cellular senescence in vitro and organismal ageing.
Retrieved from https://hdl.handle.net/1887/13335
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Stellingen behorend bij het proefschrift Cellular senescence in vitro and organismal ageing
1. Despite a huge inter-individual variability in the onset of senescence, fibroblasts from nonagenarians show a high-replicative capacity in vitro. This thesis
2. -Galactosidase activity is a reliable biomarker for the course of replicative senescence in vitro. This thesis
3. Characteristics of mixed cultures do not reflect the marked heterogeneity between single isolated stem cells obtained from human muscle. This thesis
4. Except of monogenetic premature ageing syndromes, replicative capacity of fibroblasts in vitro does not mirror key characteristics of human life histories. This thesis
5. Secreted inflammatory cytokines are crucial mediators of cellular senescence. Nat Cell Biol. 2008, 10(8):887-889
6. Age-related decline of progenitor cell activity can be rejuvenated by systemic factors. Nature. 2005, 433(7027):760-764
7. More research is needed to confirm that humans and model organisms use similar longevity-modulating pathways; the research agenda should focus on life extension strategies in humans rather than model organism in which life extension may be an artifact.
8. We don't think about diet, we don't think about prevention, and we certainly don't think about the ethics of much of what we do in the laboratory. Neal Bernard, Nature Medicine online, June 2006
9. I do feel that spiritual progress does demand at some stage that we should cease to kill our fellow creatures for the satisfaction of our bodily wants. Mahatma Gandhi 1869-1948
10. Choose a job you love, and you will never have to work a day in your life.
A.B. Maier
Leiden, 11 december 2008
