University of Groningen
Genomic heterogeneity of clear cell renal cell carcinoma
Ferronika, Paranita
DOI:
10.33612/diss.101437783
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Publication date: 2019
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Ferronika, P. (2019). Genomic heterogeneity of clear cell renal cell carcinoma. Rijksuniversiteit Groningen. https://doi.org/10.33612/diss.101437783
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Every tumour is unique (this thesis).
ccRCC is initiated by the loss of short arm of chromosome 3 and the inactivation of the VHL-HIF pathway (Sato Y et al. Nat Genet 2013; 45: 860-867).
Not all driver mutations in ccRCC have the same impact on patient survival
(this thesis).
Only multiple tumour sampling allows us to determine the trunk mutations
(this thesis).
Metastasis development could start from a punctuated evolution in a subregion of a primary tumour (this thesis).
Polyclonal seeding may be a major cause of intra-patient metastasis heterogeneity (this thesis).
Intratumour heterogeneity is a reflection of dynamic evolution of the tumour cells (Dagogo-Jack I, Shaw AT. Nat Rev Clin Oncol 2018; 15: 81-94.).
Evolution thus is merely contingent on certain processes articulated by Darwin: variation and selection (Ernst Mayr).
You are always being presented with two choices: evolve or repeat (ancient
wisdom). 1. 2. 3. 4. 5. 6. 7. 8. 9.
Paranita Ferronika, Groningen 2019 Propositions
