University of Groningen
Complement activation in chronic kidney disease and dialysis
Gaya da Costa, Mariana
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Gaya da Costa, M. (2019). Complement activation in chronic kidney disease and dialysis. Rijksuniversiteit
Groningen.
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Complement activation in
chronic kidney disease and dialysis
Cover: Denis Milani Adriano
Design and layout: Legatron Electronic Publishing, Rotterdam Printing: Ipskamp Printing, Enschede
June 2019
Copyright 2019 © Mariana Gaya Da Costa
ISBN: 978-94-034-1692-2 Printed book
ISBN: 978-94-034-1691-5 Digital version
Financial support for printing this thesis was kindly provided by: University of Groningen
University Medical Center Groningen Groningen Institute for Drug Exploration Hycult Biotechnology
ERBE Nederland BV Chipsoft
Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged.
Financial support by the Dutch Kidney Foundation for the publication of this thesis is gratefully acknowledged.
No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means without permission from the author or, when appropriate, from the publishers of the publications.
Complement activation in
chronic kidney disease and dialysis
Proefschrift
ter verkrijging van de graad van doctor aan de
Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
maandag 17 juni 2019 om 16.15 uur
door
Mariana Gaya Da Costa
geboren op 5 januari 1989
te São Paulo, Brazilië
Promotores
Prof. dr. W.J. van Son Prof. dr. J.O. Medina Pestana
Copromotores
Dr. M.A.J. Seelen Dr. F. PoppelaarsBeoordelingscommissie
Prof. dr. B. Yard Prof. dr. H.G.D. Leuvenink Prof. dr. J.L. HillebrandsTable of contents
Chapter 1 General Introduction 7
Chapter 2 The Lectin Pathway in Renal Disease: Old Concept and New Insights 13 Nephrology Dialysis Transplantation, 2018
Chapter 3 The Complement System in Dialysis: A Forgotten Story? 27 Frontiers in Immunology, 2018
Chapter 4 The Strong Predictive Value of Mannose-Binding Lectin Levels for 51
Cardiovascular Risk of Hemodialysis Patients
Journal of Translational Medicine, 2016
Chapter 5 Intradialytic Complement Activation Precedes the Development of 71
Cardiovascular Events in Hemodialysis Patients
Frontiers in Immunology, 2018
Chapter 6 Distinct Pathways Mediate Local and Systemic Complement Activation 91
in Peritoneal Dialysis
In preparation
Chapter 7 Distinct In-vitro Complement Activation by Various Intravenous 107
Iron Preparations
American Journal of Nephrology, 2017
Chapter 8 Administration of Intravenous Iron Preparations Induces 125
Complement Activation In-vivo
In submission
Chapter 9 Age and Sex-associated Changes of Complement Activity and 141
Complement Levels in a Healthy Caucasian population
Frontiers in Immunology, 2018
Chapter 10 Summary, Discussion and Future perspectives 169
Samenvatting, algemene discussie en toekomstperspectieven 177 Resumo, discussão e perspectivas futuras 185
List of publications 193
Acknowledgements 195
