University of Groningen
Hand eczema
Oosterhaven, Jart
DOI:
10.33612/diss.98242014
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Publication date: 2019
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Oosterhaven, J. (2019). Hand eczema: impact, treatment and outcome measures. https://doi.org/10.33612/diss.98242014
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Hand Eczema
Impact, Treatment and Outcome Measures
ISBN
978-94-034-1949-7 (printed version) 978-94-034-1948-0 (e-version)
© 2019, J.A.F. Oosterhaven, Groningen, The Netherlands
All rights reserved. No part of this thesis may be reproduced or transmitted in any form or by any means without prior permission from the author.
Financial support for the publication of this thesis was provided by:
Almirall, BAP Medical, DermaCura, Eurocept Homecare, Galderma, La Roche Posay, LEO Pharma, Researchfonds Dermatologie, Rijksuniversiteit Groningen, Stichting Milieu en Arbeidsdermatologie, Universitair Medisch Centrum Groningen, Vereniging voor Mensen met Constitutioneel Eczeem.
The study in chapter 9 was supported by Stichting Milieu en Arbeidsdermatologie. Cover design: Evelien Jagtman, https://evelienjagtman.com
Layout: Jart Oosterhaven
HAND ECZEMA
Impact, Treatment and Outcome Measures
PhD thesis
to obtain the degree of PhD at the
University of Groningen
on the authority of the
Rector Magnificus prof. C. Wijmenga
and in accordance with
the decision by the College of Deans.
This thesis will be defended in public on
Wednesday 16 October 2019 at 12.45 hours
by
Jan Ate Franke Oosterhaven
born on 18 November 1987
in Sneek
Supervisors
Dr. M.L.A. Schuttelaar
Prof. P.J. Coenraads
Assessment Committee
Prof. T. Agner
Prof. M. Fartasch
Prof. S.A. Reijneveld
Paranimfen / Paranymphs
Drs. F.B. Poelmann
Dr. J.H. Koetje
Table of contents
Chapter 1 General introduction 8
Section I – Impact
Chapter 2 Systematic review of cost-of-illness studies in hand eczema 22
Chapter 3 Presenteeism in a Dutch hand eczema population – 40
a cross-sectional survey Section II – Treatment
Chapter 4 Study protocol: efficacy of oral alitretinoin versus oral 70
cyclosporine A in patients with severe recurrent vesicular hand eczema (ALICsA). A randomized prospective open-label trial with blinded outcome assessment.
Chapter 5 Azathioprine treatment and drug survival in patients with 92
chronic hand eczema – results from daily practice
Chapter 6 Dupilumab treatment of very severe refractory atopic hand 98
eczema
Chapter 7 The effect of dupilumab on hand eczema in patients with 102
atopic dermatitis – an observational study Section III – Outcome measures
Chapter 8 Guideline for translation and national validation of the 122
Quality Of Life in Hand Eczema Questionnaire (QOLHEQ)
Chapter 9 Validation of the Dutch QOLHEQ 156
Chapter 10 Cross-cultural validation of the QOLHEQ 206
Chapter 11 Interpretability of the QOLHEQ 256
Chapter 12 Responsiveness and interpretability of the Hand Eczema 298
Severity Index
Chapter 13 General discussion and future perspectives 318
Chapter 14 Appendices 328
Summary 330
Samenvatting (Dutch summary) 332 Dankwoord (Acknowledgements) 334
List of publications 338
