Clinical pharmacology of the tyrosine kinase inhibitors imatinib and sunitinib Erp, P.H. van

The study was designed to determine the relationship between CYP3A4 activity and sunitinib exposure in cancer patients and additionally to evaluate the effect of sunitinib on

The aim of the present study is to identify genetic markers in sunitinib disposition, metabolism, and mechanism of action that predispose for development of common sunitinib

Next, a final model was developed by the introduction of a grapefruit juice effect on the relative bioavailability of sunitinib, resulting in an effect on the apparent clearance

Both mitotane exposed patients showed highly induced CYP3A4 activity resulting in decreased sunitinib, and midazolam exposure (including increased 1-hydroxy-midazolam exposure)

The most abundant fura- nocoumarins present in grapefruit juice are bergamottin (BG) and 6’,7’-dihydroxybergamottin (DHB). A complicating factor is that among grapefruit juices

Recently, a correlation was observed between clinical effect in CML (defined as major molecular response and complete cytogenetic response) and a minimal trough level of

It appears that midazolam exposure relates well to sunitinib exposure as well as sunitinib trough levels and explains a large part of the interpatient variability in

Sunitinib dalspiegel en sunitinib blootstelling zijn sterk gecorreleerd waardoor in vervolgonderzoek de sunitinib dalspiegel in plaats van de vele male intensievere volledige