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Cover Page

The handle http://hdl.handle.net/1887/62452 holds various files of this Leiden University dissertation

Author: Heer, Paul de

Title: Advanced imaging and spectroscopy techniques for body magnetic resonance Date: 2018-05-23

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PAuL De Heer

Advanced imaging and Spectroscopy Techniques for Body Magnetic

Resonance

Advanced imaging and Spectroscopy Techniques for Body Magnetic Resonance

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COLOFON

© 2018 Paul de Heer Leiden, the Netherlands

All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means without permission if the copyright owner.

Copyright of the published chapters is held by the publisher of the journal in which the work appeared.

The research in this thesis was supported by the Nederlands Organisatie voor Wetenschappelijk Onderzoek TOP grant and the Dutch Kidney Foundation.

Financial support by the Dutch Heart Foundation and the Dutch Kidney Foundation for the publication of this thesis is gratefully acknowledged

ISBN

978-94-90858-56-8

Printing & dtp

Drukkerij Mostert & Van Onderen, Leiden drukkerijmostert.nl

Design & concept dennisdegraaff.nl

dennis-degraaff.squarespace.com

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Advanced imaging

and Spectro

scopy Techniques

for Body

Magnetic

Resonance

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Promotiecommissie Promotores Prof. Dr. A.G. Webb Prof. Dr. H.J. Lamb Copromotor Dr. A.P.J. de Vries

Leden promotiecommissie Prof. Dr. B.P.F. Lelieveldt

Prof. Dr. T. Leiner (Universitair Medisch Centrum Utrecht) Dr. M.J. Versluis (Philips Medical Systems International B.V) Dr. H.E. Kan

Advanced Imaging and Spectroscopy Techniques for Body Magnetic Resonance

Proefschrift ter verkrijging van

de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,

volgens besluit van het College voor Promoties te verdedigen op woensdag 23 mei 2018

klokke 13:45 uur

door Paul de Heer geboren te Heemskerk

in 1983

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MR of Multi-Organ Involvement in the Metabolic Syndrome

PAGE 25

IncrEasing Signal HomO- geneity and Image Quality In Abdomi-

nal Imaging at 3T with Very High Permittivity Materials

PAGE 39

Improved Cardiac Proton Magnetic Resonance Spectroscopy at 3T Using High Permitti-

vity Pads

PAGE 51

Parameter Optimization for Reproducible Cardiac 1H-MR Spectroscopy at 3 Tesla

PAGE 71

Imaging Fatty Kidney by Clinical Proton Magnetic Resonance Spectroscopy: a First Validation and Dietary Inter- vention Study using

Porcine Kidneys

PAGE 109

Summary and general discussion

PAGE 127

Dutch summary Nederlandse samenvatting

PAGE 137

Metabolic Imaging of Human Kidney Triglyceride Content: Reproducibility of

Proton Magnetic Resonance Spectroscopy

PAGE 97

GENERAL INTRODUCTION

PAGE 9

CONTENTS

Appendices: List of publications Acknowledgements Curriculum Vitae

PAGE 141

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