University of Groningen
Ex vivo fibrosis research: 5 mm closer to human studies
Bigaeva, Emiliia
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Publication date:
2019
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Citation for published version (APA):
Bigaeva, E. (2019). Ex vivo fibrosis research: 5 mm closer to human studies. University of Groningen.
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PROPOSITIONS
following the thesis
EX VIVO FIBROSIS RESEARCH
5 mm closer to human studies
1.
Tissue slices change over time in culture; how well this process models human physiological
and pathological changes is yet to be determined. (this thesis)
2.
By performing deep sequencing of precision-cut tissue slices, we have set a baseline; the
ways one can use the derived knowledge and transform the slice model are limitless. (this
thesis)
3.
If murine tissue slices accurately predict drug efficacy in mice, it is likely that human tissue
slices can predict drug efficacy in man. (this thesis)
4.
Finding the right combination of culture conditions for PCTS opens the perspective of
creating an improved in vitro model – self-sustained, functional cultures of human PCTS. (this
thesis)
5.
Discussions about the utility of model organisms often pass at large that a model is simply
that: a model.
6.
Careful choice of the appropriate model as well as the use of complementary approaches
become imperative for improving the predictive power of preclinical research and reducing
animal use.
7.
Pressure to publish novel findings precludes investment in confirmatory studies as well as
publication of relevant negative observations.
8.
One who works with intestinal slices goes through denial, anger, bargaining, depression and,
if lucky, acceptance.
9.
The easiest way to convert millimeter to meter is to remove “milli”.
10.
Only the one who does nothing, makes no mistakes (Russian proverb); не ошибается тот,
кто ничего не делает (русская поговорка).
