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University of Groningen

Passive exercise, an effective therapy? Heesterbeek, Marelle

DOI:

10.33612/diss.95099955

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2019

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Heesterbeek, M. (2019). Passive exercise, an effective therapy? Exploring whole body vibration, therapeutic motion simulation and a combination of both. Rijksuniversiteit Groningen.

https://doi.org/10.33612/diss.95099955

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Passive Exercise, an Effective Therapy?

Exploring Whole Body Vibration, Therapeutic Motion Simulation and

a Combination of Both

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The human research described in this thesis was supported by a grant from ZonMW (grant number: 733050611).

Cover design and layout: Marelle Heesterbeek Printing: Ipskamp Printing

ISBN:978-94-034-1913-8 (Printed version) ISBN: 978-94-034-1912-1 (Electronic version)

© Marelle Heesterbeek, 2019

All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval systems, without the prior written permission of the author.

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Passive Exercise, an Effective

Therapy?

Exploring Whole Body Vibration, Therapeutic Motion Simulation and a

Combination of Both

Proefschrift

ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op

Vrijdag 13 september 2019 om 14:30 uur

door

Marelle Heesterbeek

geboren op 27 april 1991 te Winschoten

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Promotor

Prof. dr. E.A. van der Zee

Copromotor

Dr. M.J.G. van Heuvelen

Beoordelingscommissie Prof. dr. U.L.M. Eisel

Prof. dr. T. Hortobagyi Prof. dr. J. Rittweger

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TABLE OF CONTENTS

Chapter 1 General Introduction 9

Chapter 2 Whole Body Vibration, Cognition and the Brain 25

Chapter 3 Whole Body Vibration Enhances Choline Acetyltransferase-Immunoreactivity in Cortex and Amygdala

51

Chapter 4 Passive Exercise to Improve Quality of Life, Activities of Daily Living, Care Burden and Cognitive Functioning in Institutionalized Older Adults with Dementia – a Randomized Controlled Trial. Study Protocol.

61

Chapter 5 Feasibility of Three Novel Forms of Passive Exercise in a Multisensory Environment in Vulnerable Institutionalized Older Adults with Dementia

83

Chapter 6 Passive Exercise in a Multisensory Environment in Order to Manage Adverse Effects in Physically Inactive Patients with Dementia: a Randomized Controlled Trial

103

Chapter 7 Summary and General Discussion 133

Appendix I Nederlandse Samenvatting 155

Appendix II Dankwoord 163

Appendix III About the Author 169

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