University of Groningen
Gestational diabetes mellitus and fetoplacental vasculature alterations Silva Lagos, Luis
DOI:
10.33612/diss.113056657
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Silva Lagos, L. (2020). Gestational diabetes mellitus and fetoplacental vasculature alterations: Exploring the role of adenosine kinase in endothelial (dys)function. University of Groningen.
https://doi.org/10.33612/diss.113056657
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Gestational diabetes mellitus and fetoplacental
vasculature alterations
Exploring the role of adenosine kinase in endothelial
(dys)function
The research contained in this thesis was performed within:
• Department of Pathology and Medical Biology, University
Medical Center Groningen, Groningen - The Netherlands.
• Department of Obstetric and Gynecology, University
Medical Center Groningen, Groningen - The Netherlands.
• Cellular and Molecular Physiology Laboratory (CMPL),
Pontificia Universidad Católica de Chile, Santiago - Chile. Financial support for the publication of this thesis is gratefully acknowledged and was provided by the Graduate School of Medical Sciences, Comisión Nacional para la Investigación en Ciencia y Tecnología (CONICYT) (Chile), Science in Healthy Ageing and healthcaRE (SHARE) Institute, and Abel Tasman Talent program by the University of Groningen.
ISBN 9789464020472 (printed and digital)
Design and layout: L. A. Silva Lagos
Gestational diabetes mellitus and
fetoplacental vasculature alterations
Exploring the role of adenosine kinase in endothelial (dys)function
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. C Wijmenga
and in accordance with the decision of the college of Deans. This Thesis will be defended in public on Wednesday 19 February 2019 at 16:15 hours
by
Luis Alfredo Silva Lagos
born on 15 November 1990 in Santiago, Chile
Supervisors Dr. M.M. Faas Prof. T. Plösch Prof. P. de Vos Prof. L. Sobrevia Assessment Committee
Prof. H. van Goor Prof. M. C Harmsen
Paranymphs
Renate Akkerman Martin Beukema
Table of content
Chapter 1
Introduction 11
Chapter 2
Design and rationale of the thesis 19
Chapter 3
Insulin/adenosine axis linked signaling 23
Chapter 4
Role of insulin therapy in the gestational diabetes 61
mellitus-associated hENT1 reduction in the fetoplacental vasculature endothelium
Chapter 5
Adenosine kinase and cardiovascular fetal programming 75
in gestational diabetes mellitus
Chapter 6
Key adenosine metabolism regulators are altered by high
D-glucose in the fetoplacental vasculature endothelium 107
Chapter 7
Effect of high glucose and adenosine kinase in endothelial dysfunction, inflammation and angiogenic markers in the fetoplacental vasculature endothelium
127
Chapter 8
Role of adenosine kinase in the TNF-⍺ effect on endothelial dysfunction, proinflammation and adenosine metabolism regulators in the fetoplacental vasculature endothelium
145
Chapter 9
Role of adenosine kinase in the high D-glucose and TNF-⍺ effect in mitochondrial function in the fetoplacental vasculature endothelium
Chapter 10
General discussion and conclusions 177
Appendices
Summary, Samenvatting (Nederlands), Curriculum vitae and
