Cover Page
The handle http://hdl.handle.net/1887/44581 holds various files of this Leiden University dissertation
Author: Freeman, Liv
Title: Patient controlled remifentanil and epidural analgesia during labour : satisfaction, costs and safety.
Issue Date: 2016-11-30
Patient controlled remifentanil and epidural analgesia during labour.
Satisfaction, costs and safety.
Liv Freeman
Title: Patient controlled remifentanil and epidural analgesia during labour. Satisfaction, costs and safety.
ISBN 978-94-6233-435-9
Layout and printing by Gildeprint, Enschede.
The research described in this thesis was performed within the Dutch Consortium of studies in Women’s health and reproductivity.
The research described in this thesis was supported by a grant by a grant from ZonMW (Dutch Organization for Health Care Research and Development) project number 80-82310-97-11039.
Financial support for the publication of this thesis was kindly provided by: BMA BV, Chipsoft, Department of Obstetrics Leiden University Medical Center, Department of Anaesthesiology, Leiden University Medical Center, Department of Neonatology Leiden University Medical Center and Ralph Freeman.
©2016 L.M. Freeman, the Netherlands.
Patient controlled remifentanil and epidural analgesia during labour.
Satisfaction, costs and safety.
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden op gezag van de Rector Magnificus Prof. Mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op woensdag 30 november 2016
klokke 15.00 uur
door
Liv Marije Freeman
geboren te Utrecht in 1979
Promotores Prof. Dr. J.M.M. van Lith Prof. Dr. A. Dahan Co-promotor Dr. J.M. Middeldorp
Leden promotiecommissie Prof. Dr. K.W.M. Bloemenkamp (UMCU)
Dr. Med. A.A. Melber (Salem-Spital, Bern, Zwitserland) Prof. Dr. L.P.H.J. Aarts
Table of contents
Chapter 1 General introduction and outline of the thesis 7
Chapter 2 Epidural analgesia versus remifentanil patient controlled analgesia in labour: 19 a survey of practice in the Netherlands.
(Int J Clin Anesthesiol 2016;4(1):1051)
Chapter 3 Remifentanil patient controlled analgesia versus epidural analgesia in labour. 29 A multicentre randomized controlled trial.
(BMC Pregnancy Childbirth 2012;12:63)
Chapter 4 Patient controlled analgesia with remifentanil versus epidural analgesia in 37 labour: a randomised controlled equivalence trial.
(British Medical Journal 2015 Feb 23;350:h846)
Chapter 5 An economic analysis of patient controlled remifentanil and epidural 57 analgesia as pain relief in labour (RAVEL trial); a randomised controlled trial.
(Submitted)
Chapter 6 Maternal parameters in women using patient controlled remifentanil 71 and epidural analgesia for pain relief during labour; a sub analysis of the
RAVEL trial.
(Submitted)
Chapter 7 Safety of remifentanil during labour: a systematic review and meta-analysis 85 of randomised controlled trials.
(Submitted)
Chapter 8 A retrospective study on persistent pain after childbirth in the Netherlands. 103 (Journal of Pain Research 2016 Jan 9;1-8)
Chapter 9 General discussion and future perspectives 115
Chapter 10 Summary 127
Chapter 11 Nederlandse samenvatting 133
List of publications 141
Curriculum Vitae 143
Dankwoord 145
