Cover Page
The handle http://hdl.handle.net/1887/49751 holds various files of this Leiden University dissertation
Author: Welker, F.
Title: The palaeoproteomic identification of pleistocene hominin skeletal remains Issue Date: 2017-05-18
The Palaeoproteomic Identification of Pleistocene Hominin Skeletal Remains:
Towards a Biological Understanding of the Middle to Upper Palaeolithic Transition
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus Prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op 18 mei 2017
klokke 16:15 uur
door
Frido Welker
Geboren te Harderwijk, Nederland in 1991
Promotores:
Prof. dr. J.-J. Hublin (Universiteit Leiden) Prof. dr. M.J. Collins (University of York)
Promotiecommissie:
Prof. dr. J.W.M. Roebroeks (Universiteit Leiden) Prof. dr. M. van Kolfschoten (Universiteit Leiden) Prof. dr. I. Barnes (Natural History Museum, London) Dr. M. Soressi (Universiteit Leiden)
Dr. S.P. McPherron (Max-Planck-Institute for Evolutionary Anthropology, Leipzig)
This research has been made possible through funding from the Max-Planck-Gesellschaft.
Cover design: Graphical representation of the COL1α1 and COL1α2 sequence from Homo sapiens (UniProt identifiers P02452 and P08123, respectively). Protein network derived from endogenous proteins identified in Chapter 5, analyzed through STRING (v.9) and modified in Cytoscape (v.3.2.1).
“If your fingers cannot manage this knot, that is certainly nothing to wonder at;
it has become so hard because no one has tried!”
Dante Alighieri - The Divine Comedy: Paradiso Canto XXVIII.
Contents
Chapter 1 Introduction. 1
Chapter 2 Using ZooMS to identify fragmentary bone from the 35 Late Middle/Early Upper Palaeolithic sequence of
Les Cottés, France.
Chapter 3 Ancient proteins resolve the evolutionary history of 45 Darwin’s South American ungulates.
Chapter 4 Variations in glutamine deamidation for a Châtelperronian 85 bone assemblage as measured by peptide mass
fingerprinting of collagen.
Chapter 5 Palaeoproteomic evidence identifies archaic hominins 101 associated with the Châtelperronian at the Grotte du
Renne.
Chapter 6 Discussion & Conclusion. 185
Summary 207
Samenvatting 209
Acknowledgements 211
Curriculum Vitae 213
