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NMR spectroscopy and chemometrics-based analysis of grapevine

Ali, K.

Citation

Ali, K. (2011, September 20). NMR spectroscopy and chemometrics-based analysis of grapevine. Retrieved from https://hdl.handle.net/1887/17843

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/17843

Note: To cite this publication please use the final published version (if applicable).

(2)

NMR Spectroscopy and Chemometrics-based Analysis of Grapevine

PROEFSCHRIFT

Ter verkrijging van

de graad van Doctor aan de Universiteit Leiden,

op gezag van Rector Magnificus prof. mr. P. F. Van der Heijden, volgens besluit van het College voor Promoties

te verdedigen op donderdag 20

th

September 2011 klokke 11:15 uur

door

Kashif Ali

geboren te Karachi, Pakistan

in 1981

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Promotiecommissie

Promotor Prof. Dr. R. Verpoorte

Co promotor Dr. Y. H. Choi

Overige Leiden Prof. Dr. C. J. ten Cate Prof. Dr. P. G. L. Klinkhamer Dr. F. Maltese

Dr. A. M. Fortes

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To My Parents...!!!

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Kashif Ali

NMR spectroscopy and chemometrics-based analysis of grapevine Printed by: Wӧhrmann Print Service

ISBN

Cover designed by:

Tausif Ali

Sr. Web and Graphic Desginer Software Technology Inovators (STI)

Sir Syed University of Engineering and Technology (SSUET)

Karachi-Pakistan

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Contents

Chapter 1 General introduction 1

Chapter 2 Metabolic constituents of grapevine and grape-derived products 7

Chapter 3 Metabolomics: platforms, applications, and perspectives for grape and wine research

35

Chapter 4 Pre-analytical method for NMR-based grape metabolic fingerprinting and chemometrics

59

Chapter 5 Monitoring biochemical changes during grape berry development in Portuguese cultivars by NMR spectroscopy

77

Chapter 6 NMR spectroscopy and chemometrics as a tool for anti-TNFα activity screening in grapes

99

Chapter 7 Metabolic characterization of Palatinate German white wines according to sensory attributes, varieties, and vintages using NMR spectroscopy and multivariate data analyses

121

Chapter 8 Red wines attenuates TNFα production hystiocytic lymphoma cell line: An NMR spectroscopy and chemometrics-based study

143

Chapter 9 NMR metabolic fingerprinting-based identification of grapevine metabolites associated with Downy Mildew resistance

161

Chapter 10 NMR-based study of alterations in grapevine leaf metabolism upon inoculation with Plasmapora viticola

179

Chapter 11 General discussion, conclusions, and perspectives 197

Summary 207

Samenvatting 211

References 217

Acknowledgements 237

Curriculum vitae 239

List of publications 241

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