Hypopituitarism : clinical assessment in different conditions
Kokshoorn, N.E.
Citation
Kokshoorn, N. E. (2011, December 7). Hypopituitarism : clinical assessment in different conditions. Retrieved from https://hdl.handle.net/1887/18194
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Hypopituitarism
Clinical assessment in diff erent conditions
Nieke E. Kokshoorn
ISBN 978-90-9026381-6
Cover Nike the Goddess of Victory Cover design Nieke Kokshoorn
Lay out Merel Leeuwenburgh
Printed by De Swart, Th e Hague, Th e Netherlands
Part of this research (Chapter 3) was fi nancially supported by Pfi zer BV, Capelle aan den IJssel, Th e Netherlands
Publication of this thesis was fi nancially supported by Pfi zer BV, Goodlife BV, Novo Nordisk BV, Novartis Pharma BV, Ipsen Farmaceutica BV
© 2011, Nieke E. Kokshoorn, Leiden, Th e Netherlands. All rights reserved.
No part of this thesis may be reproduced or transmitted in any form, by any means, without prior written permission of the author.
Voor Papa en Mama, Aan mijn lieve Oma
Hypopituitarism
Clinical assessment in diff erent conditions
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnifi cus prof.mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op woensdag 7 december 2011 klokke 15.00 uur
door
Nieke Eva Kokshoorn
geboren te Voorburg in 1982
Promotiecommissie
Promotores Prof. dr. J.W.A. Smit Prof. dr. J.A. Romijn Co-promotor Dr. A.M. Pereira
Overige leden Prof. dr. A.R.M.M. Hermus, UMC St. Radboud Prof. dr. J.H. Bolk
Prof. dr. H. Pijl Dr. N.R. Biermasz
7
Contents
Chapter 1 General introduction and outline of this thesis 9 Chapter 2 Clinical review: Hypopituitarism following trau-
matic brain injury – the prevalence is aff ected by the use of diff erent dynamic tests and diff erent nor-
mal values 37
Eur J Endocrinol. 2010 Jan;162(1): 11–18
Chapter 3 Low prevalence of hypopituitarism aft er traumatic
brain injury – a multi-center study 75 Eur J Endocrinol. 2011 Aug;165(2):225–31.
Chapter 4 Th e use of an early postoperative CRH test to assess adrenal function aft er transsphenoidal surgery for
pituitary adenomas 95
Pituitary . 2011 Sep 9. [Epub ahead of print]
Chapter 5 Low incidence of adrenal insuffi ciency aft er transsphenoidal surgery in patients with acromegaly:
a long-term follow-up study 119
J Clin Endocrinol Metab. 2011 Jul;96(7):E1163–70.
Chapter 6 Pituitary dysfunction in adult patients aft er cranial
radiotherapy: a systematic review and meta-analysis 141 J Clin Endocrinol Metab. 2011 Aug;96(8):2330–40
Chapter 7 Growth hormone replacement therapy in elderly growth hormone defi cient patients: a systematic re-
view 171
Eur J Endocrinol. 2011 May;164(5):657–65.
8
CONTENTS
Chapter 8 General discussion and summary 197
Chapter 9 Nederlandse samenvatting 219
Curriculum Vitae 235
List of publications 239
Notes 243
