Non-invasive sampling methods of inflammatory biomarkers in asthma and allergic rhinitis
Boot, J.D.
Citation
Boot, J. D. (2009, September 10). Non-invasive sampling methods of inflammatory biomarkers in asthma and allergic rhinitis. Retrieved from https://hdl.handle.net/1887/13967
Version: Corrected Publisher’s Version License:
Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/13967
Note: To cite this publication please use the final published version (if
applicable).
non - invasive sampling methods of infl ammatory biomarkers in asthma and allergic rhinitis
Non-invasive sampling methods of inflammatory
biomarkers in asthma and allergic rhinitis
proefschrif t
ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van de Rector Magnificus prof. mr. P.F. van der Heijden, volgens besluit van het College voor
Promoties te verdedigen op donderdag 10 september 2009 klokke 11.15 uur
door
Johan Diderik Boot, geboren te Chertsey, Engeland in 1977
promotores
Prof. A.F. Cohen Prof. P.J. Sterk
co -promotor Dr. Z. Diamant
overige leden Prof. K.F. Rabe
Prof. J.C. Virchow, University of Rostock, Germany Prof. R. Gerth van Wijk, Erasmus University Medical Centre
The printing of this thesis was financially supported by the foundation
‘Centre for Human Drug Research’, Leiden, The Netherlands design Caroline de Lint, Voorburg (caro@delint.nl)
section 1 introduction
1 General introduction and outline of the thesis
2 A critical appraisal of methods used in early clinical development of novel drugs for the treatment of asthma.
section 2 clinical studies – allergic asthma
3 Effect of an nk1/nk2 receptor antagonist on airway responses and inflammation to allergen in asthma.
4 Reversal of the late asthmatic response increases exhaled nitric oxide.
5 Comparison of exhaled nitric oxide measurements between niox mino electrochemical and Ecomedics chemiluminescence analyzer.
6 Combining alternative sputum processing methods & sensitive detection techniques for biomarker analysis: a feasibility study
section 3 clinical studies – allergic rhinitis
7 Applicability and reproducibility of biomarkers for the evaluation of anti-inflammatory therapy in allergic rhinitis.
8 Nasal nitric oxide: longitudinal reproducibility and the effects of a nasal allergen challenge in patients with allergic rhinitis.
section 4 clinical studies – allergic asthma & allergic rhinitis
9 Cleaved secretory leukocyte protease inhibitor as a biomarker of chymase activity in allergic airway disease
section 5 discussion
10 Summary and general discussion 11 Samenvatting
Bibliography Curriculum Vitae
7 9 23
57 59
79
85
95 111 113
131
147 149
165 167 183 191 192
