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Cover Page The handle https://hdl.handle.net/1887/3157141 holds various files of this Leiden University dissertation. Author: Ng, A. Title:

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Cover Page

The handle https://hdl.handle.net/1887/3157141 holds various files of this Leiden

University dissertation.

Author: Ng, A.

Title: Multimodality imaging in metabolic heart disease

Issue Date:

2021-03-23

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Multimodality Imaging in

Metabolic Heart Disease

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Multimodality Imaging In Metabolic Heart Disease

The studies described in this thesis were performed at the Department of Cardiology of Leiden University Medical Center, Leiden, The Netherlands, and Department of Cardiol-ogy, Princess Alexandra Hospital, Brisbane, Queensland, Australia

Cover: Arnold CT Ng Lay-out and print: ISBN: 978-94-6361-534-1

Copyright© Arnold CT Ng, Leiden, The Netherlands. All rights reserved. No part of this book may be reproduced or transmitted, in any form or by any means, without permis-sion of the author.

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Multimodality Imaging in Metabolic Heart Disease

Proefschrift ter verkrijging van

de graad van Doctor aan de Universiteit Leiden, op gezag van rector magnificus prof.dr.ir. H. Bijl, volgens besluit van het college voor promoties

te verdedigen op dinsdag 23 maart 2021 klokke 10.00 uur

door Arnold CT Ng Geboren te Malaysia in 1976

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Promotor

Prof. Dr. .J. Bax

Co-promotor

Dr. V. Delgado

Leden promotiecommissie

Prof.dr.ir. J.H.C. Reiber Prof.dr. N.R. Biermasz Prof. Dr. J.W de Fijter

Prof. Dr. F. Cosentino (Karolinska University Hospital, Sweden)

Prof. Dr. D. Leung (South Western Sydney Clinical School, University of New South Wales, Sydney, Australia)

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Dedicated to my family: Carolina, Allison, Adelyne, Diyen

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TabLe of ConTenTs

General introduction and outline of thesis 9 Chapter 1 Multimodality Imaging in Diabetic Heart Disease 25

Curr Probl Cardiol. 2011;36(1):9-47

Chapter 2 Findings from Left Ventricular Strain and Strain Rate Imaging in Asymptomatic Patients with Type 2 Diabetes Mellitus

65

Am J Cardiol. 2009;104(10):1398-401

Chapter 3 Impact of Diabetes and Increasing Body Mass Index Category on Left Ventricular Systolic and Diastolic Function

77

J Am Soc Echocardiogr. 2018;31(8):916-925

Chapter 4 Myocardial Steatosis and Biventricular Strain and Strain Rate Imaging in Patients with Type 2 Diabetes Mellitus

99

Circulation. 2010;122(24):2538-44

Chapter 5 Association Between Diffuse Myocardial Fibrosis by Cardiac Magnetic Resonance Contrast-Enhanced T1 Mapping and Subclinical Myocardial Dysfunction in Diabetic Patients: A Pilot Study

115

Circ Cardiovasc Imaging. 2012 Jan;5(1):51-9

Chapter 6 Impact of Epicardial Adipose Tissue, Left Ventricular Myocardial Fat Content and Interstitial Fibrosis on Myocardial Contractile Function

137

Circ Cardiovasc Imaging. 2018;11(8):e007372

Chapter 7 Defining Subclinical Myocardial Dysfunction and Implications for Patients with Diabetes Mellitus and Preserved Ejection Fraction

159

Am J Cardiol. 2019;124(6):892-898

Summary and conclusions 177

Samenvatting en conclusies 183

List of publications 187

Curriculum Vitae 203

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