Influence of molecular properties and delivery system design on the transfollicular transport across the skin
Grams, Ylva Yvonne
Citation
Grams, Y. Y. (2005, January 12). Influence of molecular properties and delivery system design on the transfollicular transport across the skin. Retrieved from
https://hdl.handle.net/1887/598
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Influence of molecular properties and delivery system design on the transfollicular transport
across the skin
Influence of molecular properties and delivery system design on the transfollicular transport
across the skin
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van de Rector Magnificus Dr.D.D.Breimer,
hoogleraar in de faculteit der W iskunde en Natuurwetenschappen en die der Geneeskunde,
volgens besluit van het College voor Promoties te verdedigen op woensdag 12 januari 2005
klokke 16.15 uur
door
Ylva Yvonne Grams
geboren te W ehrda/Marburg in 1972
Promotiecommissie
Promotor: Prof. Dr. J.A. Bouwstra
Referent: Prof. Dr. rer. nat. J. Lademann (Charité Berlin, Germany) Overige leden: Prof. Dr. Th.J.C. van Berkel
Prof. Dr. H.E. Junginger Prof. Dr. G.J. Mulder Prof. Dr. H.P. Spaink
The investigations described in this thesis were performed at the Division of Drug Delivery Technology of the Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden.
The investigations described in this thesis were financially supported by Unilever Research, Port Sunlight, UK.
ALTA sobre la tierra te pusieron, dura, hermosa araucaria de los australes montes, torre de Chile, punta del territorio verde, pabellón del invierno, nave de la fragancia.
(Pablo Neruda, ODA A LA ARAUCARIA ARAUCANA)
I
Table of contents
CHAPTER I General introduction 9
CHAPTER II A new method to determine the distribution of a 31 fluorophore in scalp skin with focus on hair follicles
CHAPTER III Penetration and distribution of three lipophilic probes in 45 vitro in human skin focussing on the hair follicle
CHAPTER IV Permeant lipophilicity and vehicle composition influence 63 on accumulation of dyes in hair follicles of human skin
CHAPTER V On-line visualisation of dye diffusion in fresh unfixed 79 human skin
CHAPTER VI Time and depth resolved visualisation of the diffusion 97 of a lipophilic dye into the hair follicle of fresh unfixed
human scalp skin
CHAPTER VII On-line diffusion profile of a lipophilic model dye in 115 different depth of a hair follicle in human scalp skin
CHAPTER VIII Summary and future perspectives 133
CHAPTER IX Samenvatting en Toekomstperspectieven 145
ACKNOW LEDGEMENTS 157
CURRICULUM VITAE 159
LIST OF PUBLICATIONS 161
