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Neonatal management and outcome in red cell alloimmunization

Smits-Wintjens, V.E.H.J.

Citation

Smits-Wintjens, V. E. H. J. (2012, February 15). Neonatal management and outcome in red cell alloimmunization. Retrieved from

https://hdl.handle.net/1887/18485

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/18485

Note: To cite this publication please use the final published version (if applicable).

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Neonatal management and outcome in red cell alloimmunization

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ISBN/EAN: 978-90-9026589-6

Cover-photos: Mika van Zon, participant in the LOTUS study.

Mika’s photos (a few days after birth and at the age of 5) are published with kind permission of his parents.

Layout and printing: Pasmans Offsetdrukkerij BV, Den Haag.

The printing of this thesis was financially supported by Willem-Alexander Kinderziekenhuis, Leiden.

© 2012 V.E.H.J. Smits-Wintjens, Leiden, The Netherlands.

All rights reserved. No part of this publication may be reproduced, stored or transmitted in any way or by any means, without the prior permission of the author or the copyright-owning journals for previously published chapters.

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Neonatal management and outcome in red cell alloimmunization

Proefschrift

ter verkrijging van

de graad van doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. P.F. van der Heijden,

volgens besluit van het College voor Promoties te verdedigen op woensdag 15 februari 2012

klokke 13:45 uur

door

Vivianne Elise Huberta Johanna Smits - Wintjens geboren te Maastricht

in 1972

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Promotiecommissie

Promotor : Prof. dr. F.J. Walther Copromotor : dr. E. Lopriore

Overige leden : Prof. dr. A. Brand

Prof. dr. R. Devlieger, Katholieke Universiteit Leuven, België dr. P.H. Dijk, Universitair Medisch Centrum Groningen dr. D. Oepkes

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Aan mijn ouders, Robert, Koen, Tijn en Lieke

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Table of contents

Chapter 1 General introduction and outline of the thesis . . . .

Chapter 2 Rhesus hemolytic disease of the newborn: postnatal management, associated morbidity and long-term outcome

Semin Fetal Neonatal Med 2008; 13:265-271 . . . .

Chapter 3 Intravenous immunoglobulin in neonates with Rhesus hemolytic disease: a randomized controlled trial

Pediatrics 2011; 127:680-686 . . . .

Chapter 4 Bacillus cereus cerebral abscesses in a term neonate with Rhesus hemolytic disease treated with exchange transfusion

J Pediatr Inf Dis 2010; 5(3):277-280 . . . .

Chapter 5 Neonatal morbidity after exchange transfusion for red cell alloimmune hemolytic disease

Submitted . . . .

Chapter 6 Cholestasis in neonates with red cell alloimmune hemolytic disease:

incidence, risk factors and outcome

Neonatology; In press . . . .

Chapter 7 Thrombocytopenia at birth in neonates with red cell alloimmune hemolytic disease

Vox Sang 2011; Epub ahead of print . . . .

Chapter 8 Top-up transfusions in neonates with Rhesus hemolytic disease in relation to exchange transfusions

Vox Sang 2010; 99(1):65-70 . . . .

Chapter 9 Exchange transfusions and top-up transfusions in neonates with Kell hemolytic disease

Vox Sang 2010; 100(3):312-316 . . . .

9

19

35

49

57

71

83

95

107

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Chapter 10 Long-term neurodevelopmental outcome after intrauterine transfusion for fetal alloimmune anemia: the LOTUS study

Am J Obstet Gynecol 2011; Epub ahead of print . . . .

Chapter 11 General discussion and future perspectives . . . .

Chapter 12 Summary . . . .

Chapter 13 Samenvatting . . . .

List of abbreviations . . . .

Authors and affiliations . . . .

Curriculum Vitae . . . .

Publications . . . .

Dankwoord . . . .

117 133 147 153

163 165 167 169 171

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