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University of Groningen

Adrenal tumors Buitenwerf, Edward

DOI:

10.33612/diss.96963155

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date:

2019

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Buitenwerf, E. (2019). Adrenal tumors: optimization of diagnostic strategies and patient management.

Rijksuniversiteit Groningen. https://doi.org/10.33612/diss.96963155

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ADRENAL TUMORS

optimization of diagnostic strategies and patient management

Edward Buitenwerf

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Adrenal tumors

optimization of diagnostic strategies and patient management Edward Buitenwerf

ISBN/EAN:

978-94-034-1889-6 978-94-034-1888-9

Copyright © Edward Buitenwerf

All rights reserved. No part of this thesis may be reproduced, stored or transmitted in any way or by any means without the prior permission of the author, or when applicable, of the publishers of the scientific papers.

Cover design: Huub Lunter

Layout and design: Daniëlle Balk, persoonlijkproefschrift.nl Printing: Ridderprint BV | www.ridderprint.nl

Financial support for printing of this thesis was kindly provided by The Endocrinology Fund (as part of the Ubbo Emmius Fund), Ipsen Pharmaceuticals B.V., Graduate School of Medical Sciences/University Medical Center Groningen and University of Groningen.

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Adrenal tumors

optimization of diagnostic strategies and patient management

Proefschrift

Ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op woensdag 9 oktober 2019 om 16:15 uur

door

Edward Buitenwerf geboren op 17 maart 1989

te Bedum

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Promotores Prof. dr. T.P. Links Dr. R.P.F. Dullaart Copromotor Dr. M.N. Kerstens Beoordelingscommissie Prof. dr. W.W. de Herder Prof. dr. M.M.R.F. Struys Prof. dr. M. Fassnacht Paranimfen

A.M.A Berends K. Eijkelenkamp

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Contents

Chapter 1 General introduction and scope of the thesis 7 Part I Adrenal cortex: evaluation of adrenal steroidogenesis

and its relationship with lipoproteins

19 Chapter 2 Determination of reference intervals for urinary steroid profiling

using a newly validated GC-MS/MS method

21 Clin Chem Lab Med. 2017;56:103-112.

Chapter 3 High density lipoproteins and adrenal steroidogenesis: a population-based study

49

J Clin Lipidol. 2017;11:469-476.

Chapter 4 Cholesterol delivery to the adrenal glands estimated by adrenal venous sampling: an in vivo model to determine the contribution of circulating lipoproteins to steroidogenesis in humans

65

J Clin Lipidol. 2017;11:733-738.

Part II Adrenal medulla: optimization of current diagnostic strategies for PPGL

79 Chapter 5 Incidence of pheochromocytoma and sympathetic paraganglioma

in the Netherlands: A nationwide study and systematic review

81 Eur J Intern Med. 2018;51:68-73.

Chapter 6 Unenhanced CT imaging is highly sensitive to exclude pheochromocytoma: a multicenter study

103 Eur J Endocrinol. 2018;178:431-437.

Chapter 7 Diagnostic accuracy of CT imaging to exclude phaeochromocytoma:

a systematic review meta-analysis and cost analysis

119 Mayo Clin Proc. Accepted

Part III Adrenal medulla: optimizing perioperative hemodynamic stability in PPGL - The PRESCRIPT study

145 Chapter 8 The Haemodynamic Instability Score: development and validation

of a new rating method of intraoperative haemodynamic instability

147

Eur J Anaesthesiol. 2019;36:290-296

Chapter 9 Randomized trial comparing the efficacy of phenoxybenzamine and doxazosin for preoperative treatment of patients with a pheochromocytoma

163

submitted

Chapter 10 Summary and General Discussion 181

Chapter 11 Nederlandse samenvatting 209

Dankwoord 215

List of publications 221

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